Discovery, Structure, and Anticancer Activity of an Iridium Complex of Diselenobenzoquinone

被引：74

作者：

Amouri, Hani ^{[1
]}

Moussa, Jamal ^{[1
]}

Renfrew, Anna K. ^{[3
]}

Dyson, Paul J. ^{[3
]}

Rager, Marie Noelle ^{[2
]}

Chamoreau, Lise-Marie ^{[1
]}

机构：

[1] Univ Paris 06, Inst Parisien Chim Mol, IPCM, CNRS,UMR 7201, F-75252 Paris 05, France

[2] Ecole Natl Super Chim Paris, NMR Facitilties, F-75231 Paris 05, France

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 41期

基金：

瑞士国家科学基金会;

关键词：

coordination modes; iridium; quinones; reactive intermediates; selenium; QUINONE METHIDE COMPLEXES; CRYSTAL-STRUCTURE; REACTIVITY; SELENIUM; LINKERS; SPAN;

D O I：

10.1002/anie.201002532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Caught in the act: The first stable η4-diseleno-ρ- benzoquinone complex, [Cp*Ir(η4-C6H 4Se2)], has been isolated. The X-ray structure (see picture; Ir magenta, Se yellow) confirms the coordination of the elusive diselenobenzoquinone intermediate. The anticancer activity of this complex was compared to related oxygen and sulfur analogues; only the diseleno complex was cytotoxic, having a comparable activity to cisplatin. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7530 / 7533

页数：4

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