Mucins and immune reactions to mucins in ulcerative colitis

被引：27

作者：

Hayashi, T

Ishida, T

Motoya, S

Itoh, F

Takahashi, T

Hinoda, Y

Imai, K

机构：

[1] Sapporo Med Univ, Dept Internal Med 1, Sapporo, Hokkaido, Japan

[2] Yamaguchi Univ, Sch Med, Dept Clin Lab Sci, Ube, Yamaguchi 755, Japan

来源：

DIGESTION | 2001年 / 63卷

关键词：

MUC1; MUC2; goblet cell; sulphation; antibody-dependent cell-mediated cytotoxicity cytotoxic T lymphocytes;

D O I：

10.1159/000051907

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ulcerative colitis (UC) is an inflammatory bower disease of undetermined etiology. Mucins, mainly produced by goblet cells, protect colon cells from various kinds of stress. Alteration in the quality or quantity of mucins may be the cause of the disease. Another possible cause is immune reactions to co ion ic cells. Anti-MUC1 antibodies were detected in the sera of patients with UC. Antibodies would destroy the colonic cells through antibody-dependent cell-mediated cytotoxicity. We reviewed the significance of mucins as well as humoral and cellular immunity in the pathogenesis of UC. Copyright (C) 2001 S. Karger AG, Basel.

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收藏

页码：28 / 31

页数：4

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