Spongosine Production by a Vibrio harveyi Strain Associated with the Sponge Tectitethya crypta

被引：36

作者：

Bertin, Matthew J. ^{[1
]}

Schwartz, Sarah L. ^{[2
]}

Lee, John ^{[1
,3
]}

Korobeynikov, Anton ^{[4
,5
,6
]}

Dorrestein, Pieter C. ^{[7
]}

Gerwick, Lena ^{[1
]}

Gerwick, William H. ^{[1
,7
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92037 USA

[2] Univ Calif San Diego, Environm Syst Program, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Chem & Biochem Program, La Jolla, CA 92093 USA

[4] St Petersburg State Univ, Dept Stat Modeling, St Petersburg 199034, Russia

[5] St Petersburg Acad Univ, Algorithm Biol Lab, St Petersburg, Russia

[6] St Petersburg State Univ, Ctr Algorithm Biotechnol, St Petersburg 199034, Russia

[7] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 03期

基金：

俄罗斯科学基金会;

关键词：

MOLECULAR NETWORKING; THEONELLA-SWINHOEI; MARINE SPONGE; BIOSYNTHESIS; METABOLITES; BACTERIA; REVEALS;

D O I：

10.1021/np5009762

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Spongosine (1), deoxyspongosine (2), spongothymidine (Ara T) (3), and spongouridine (Ara U) were isolated from the Caribbean sponge Tectitethya crypta and given the general name "spongonucleosides". Spongosine, a methoxyadenosine derivative, has demonstrated a diverse bioactivity profile including anti-inflammatory activity and analgesic and vasodilation properties. Investigations into unusual nucleoside production by T. crypta-associated microorganisms using mass spectrometric techniques have identified a spongosine-producing strain of Vibrio harveyi and several structurally related compounds from multiple strains.

引用

页码：493 / 499

页数：7

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