Age-dependent variation of fecal calprotectin in cystic fibrosis and healthy children

被引：40

作者：

Garg, Millie ^{[1
]}

Leach, Steven T. ^{[1
]}

Coffey, Michael J. ^{[1
]}

Katz, Tamarah ^{[2
]}

Strachan, Roxanne ^{[3
]}

Pang, Tamara ^{[1
]}

Needham, Bronwen. ^{[4
]}

Lui, Kei ^{[1
,5
]}

Ali, Fathalla ^{[1
]}

Day, Andrew S. ^{[6
]}

Appleton, Laura ^{[6
]}

Moeeni, Vesal ^{[6
]}

Jaffe, Adam ^{[1
,3
]}

Ooi, Chee Y. ^{[1
,7
]}

机构：

[1] Univ New S Wales, Sch Womens & Childrens Hlth, Med, Sydney, NSW, Australia

[2] Sydney Childrens Hosp, Dept Nutr & Dietet, High St, Randwick, NSW 2031, Australia

[3] Sydney Childrens Hosp, Dept Resp Med, High St, Randwick, NSW 2031, Australia

[4] Univ Sydney, Sydney Med Program, Camperdown, NSW 2050, Australia

[5] Royal Hosp Women, Dept Newborn Care, Barker St, Randwick, NSW 2031, Australia

[6] Univ Otago, Dept Pediat, 2 Riccarton Ave, Canterbury 8011, New Zealand

[7] Sydney Childrens Hosp, Dept Gastroenterol, High St, Randwick, NSW 2031, Australia

来源：

JOURNAL OF CYSTIC FIBROSIS | 2017年 / 16卷 / 05期

关键词：

Leukocyte L1 antigen complex; Calprotectin; S100; proteins; Cystic fibrosis; Gastrointestinal inflammation; Pediatrics; PANCREATIC-FUNCTION; SMALL-INTESTINE; L1; PROTEIN; GUIDELINES; MICROBIOTA; DYSBIOSIS; INFANTS; MOUSE;

D O I：

10.1016/j.jcf.2017.03.010

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Fecal calprotectin may be used as a non-invasive method to assess the effect of novel therapies on the gut in cystic fibrosis (CF). Method: Stools from CF patients and healthy controls (HC) (0-10 years old) were prospectively collected for evaluation of temporal trends. Results: 130 CF samples (64 subjects) and 114 HC samples (101 subjects) were collected. Overall, fecal calprotectin levels were different in CF patients and HC from 0 to 10 years (P = 0.0002). Fecal calprotectin in CF was significantly lower than HC from 0 to 1 years (P = 0.03) and demonstrated an upward trajectory until 4 years. From >4 to 10 years calprotectin was consistently higher in CF patients compared with HC (P = 0.007). Conclusions: Fecal calprotectin levels in children with CF and HC were age-dependent and had distinct trajectories. Careful interpretation of calprotectin is required if used in drug trials for CF, particularly in children less than 4 years old. (C) 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

引用

页码：631 / 636

页数：6

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