Mouse models for understanding the growth hormone insulin-like growth factor-I axis

被引：5

作者：

Rosen, Clifford J. ^{[1
]}

机构：

[1] St Joseph Hosp, Maine Ctr Osteoporosis Res & Educ, Bangor, ME 04401 USA

来源：

HORMONE RESEARCH | 2007年 / 68卷

关键词：

growth hormone; insulin-like growth factors; mouse; bone mass;

D O I：

10.1159/000110461

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Mouse models that include spontaneous mutations, as well as those carrying allelic differences, have been extremely useful in clarifying the role of skeletal and circulating insulin-like growth factor I (IGF-I) in peak bone acquisition. The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass. Conclusions: Mouse models continue to deepen our understanding of IGR-I signaling and the role of IGR-I in determining marrow stromal cell fate. Copyright (c) 2007 S. Karger AG, Basel.

引用

页码：2 / 4

页数：3

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