The potential effect and delivery of piperine on chemoresistant breast cancer

被引：1

作者：

Wihandani, Desak Made ^{[1
]}

Saputra, I. Putu Gede Septiawan ^{[2
]}

Remitha, Ni Putu Sri Indrani ^{[2
]}

Indrakusuma, Anak Agung Bagus Putra ^{[2
]}

Adiputra, Putu Anda Tusta ^{[3
]}

Supadmanaba, I. Gede Putu ^{[1
]}

机构：

[1] Univ Udayana, Dept Biochem, Fac Med, Bali, Indonesia

[2] Univ Udayana, Fac Med, Bali, Indonesia

[3] Univ Udayana, Sanglah Gen Hosp, Div Surg Oncol, Dept Surg, Denpasar, Indonesia

来源：

BALI MEDICAL JOURNAL | 2021年 / 10卷 / 02期

关键词：

breast cancer; chemoresistance; delivery; effect; Piperine; EPITHELIAL-MESENCHYMAL TRANSITION; STERICALLY STABILIZED LIPOSOMES; CARCINOMA KB CELLS; IN-VITRO; ACID; NANOPARTICLES; METASTASIS; EXPRESSION; OXIDATION; EFFICACY;

D O I：

10.15562/bmj.v10i2.2247

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Breast cancer is the most common malignancy in women worldwide. Breast cancer is associated with a high mortality rate and health-related economic burden. Breast cancer patients have a low 5-year life expectancy when diagnosed at advanced stages. Besides, the emergence of chemoresistance in breast cancer has led to an intense search for alternative anticancer agents. One of the potential anticancer compounds is Piperine. Several studies had found that Piperine has anticancer effects such as anti-proliferation, induces apoptosis, anti-migration or anti-metastasis, chemo-enhancer or chemosensitizer, cytotoxic agents, anti-angiogenesis, immune response modulators, and self-renewal inhibitor for cancer stem cells. Several delivery agents such as PLGA, PEG-PLGA and liposomes have been studied to improve Piperine's delivery and have shown good results. Therefore, the combination of Piperine and nanoparticles is a potential anticancer agent, especially in breast cancer.

引用

页码：608 / 616

页数：9

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