HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis

被引：2

作者：

Zhao, Jing ^{[1
,2
]}

Wang, Guoliang ^{[3
]}

Wang, Guixiang ^{[1
,2
]}

Wang, Hua ^{[1
,2
]}

Wang, Shengcai ^{[1
,2
]}

Tai, Jun ^{[1
,2
]}

Tang, Lixing ^{[1
,2
]}

Gui, Jingang ^{[3
]}

Zhang, Jie ^{[1
,2
]}

Ni, Xin ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing Key Lab Pediat Dis Otolaryngol Head & Nec, Beijing 100045, Peoples R China

[2] Capital Med Univ, Beijing Childrens Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100045, Peoples R China

[3] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Key Lab Major Dis Children,Minist Educ, Beijing, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 2017年 / 102卷

基金：

中国国家自然科学基金;

关键词：

Aggressive; Chinese Han population; HLA; Human papilloma virus (HPV); Juvenile-Onset recurrent respiratory Papillomatosis (JORRP); HLA; RISK; ASSOCIATIONS;

D O I：

10.1016/j.ijporl.2017.04.017

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Juvenile-Onset recurrent respiratory papillomatosis (JORRP) is a rare benign neoplasm of the respiratory mucosa caused by human papilloma virus. Previous studies on the possible associations between HLA alleles and JORRP have shown various results in different ethnic groups. The present study aims to investigate the association between JORRP and HLA class II DRBland DQB1 alleles in Chinese Han children. We found that the frequencies of HLA-DRB1*03:01 (p(c) = 0.0378, OR = 4.8) and HLA-DQB1 *02:01 (p(c) = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1*03:01 allele significantly correlated with aggressive JORRP (r = 0.467, p = 0.009). This was the first study on the HLA alleles in Chinese Han patients with JORRP. Future studies are required to further elucidate the correlation of HLA class II alleles and susceptibility to JORRP. (C) 2017 Published by Elsevier Ireland Ltd.

引用

页码：119 / 122

页数：4

共 20 条

[1] Recurrent respiratory papillomatosis: a complex defect in immune responsiveness to human papillomavirus-6 and-11 [J].