Influenza Immunization in the Context of Preexisting Immunity

被引：16
作者：
Linderman, Susanne L. [1 ,2 ]
Ellebedy, Ali H. [1 ,2 ,3 ]
Davis, Carl [1 ,2 ]
Eberhardt, Christiane S. [1 ,2 ,4 ,5 ,6 ]
Antia, Rustom [7 ]
Ahmed, Rafi [1 ,2 ]
Zarnitsyna, Veronika I. [1 ,2 ]
机构：
[1] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Univ Geneva, Ctr Vaccinol, CH-1205 Geneva, Switzerland
[5] Univ Geneva, Univ Hosp Geneva, Dept Pediat, CH-1205 Geneva, Switzerland
[6] Univ Geneva, Fac Med, CH-1205 Geneva, Switzerland
[7] Emory Univ, Dept Biol, Atlanta, GA 30322 USA
来源：
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2021年 / 11卷 / 11期
关键词：
REACTIVE ANTIBODY-RESPONSES; MEMORY B-CELL; CONSTRUCTS PROTECT; HEMAGGLUTININ-STEM; VACCINE; VIRUS; H5N1; INDUCTION; HA;
D O I：
10.1101/cshperspect.a040964
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Although we develop influenza immunity from an early age, it is insufficient to prevent future infection with antigenically novel strains. One proposed way to generate long-term protective immunity against a broad range of influenza virus strains is to boost responses to the conserved epitopes on the hemagglutinin, the major surface glycoprotein on the influenza virus. Influenza-specific humoral immunity comprises a large fraction of the overall immune memory in humans, and it has been long recognized that preexisting immunity to influenza shapes the response to subsequent influenza infections and vaccinations. However, the mechanisms by which preexisting immunity modulates the response to influenza vaccination are still not completely understood. Using a set of mathematical models, we explore several hypotheses that may contribute to diminished boosting of antibodies to conserved epitopes after repeated vaccinations.
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页数：13
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