Alternative method for the reduction of aromatic nitro to amine using TMDS-iron catalyst system

被引：77

作者：

Pehlivan, Leyla ^{[1
]}

Metay, Estelle ^{[1
]}

Laval, Stephane ^{[1
]}

Dayoub, Wissam ^{[1
]}

Demonchaux, Patrice ^{[2
]}

Mignani, Gerard ^{[3
]}

Lemaire, Marc ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, ICBMS, Lab Catalyse & Synthese Organ,UMR5246, F-69622 Villeurbanne, France

[2] Minakem SAS, F-59310 Beuvry La Foret, France

[3] Lyon Res Ctr, F-69192 St Fons, France

来源：

TETRAHEDRON | 2011年 / 67卷 / 10期

关键词：

SELECTIVE REDUCTION; CHEMOSELECTIVE HYDROGENATION; HYDROSILYLATION; PLATINUM; NITROCOMPOUNDS; NITROARENES;

D O I：

10.1016/j.tet.2010.12.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The system 1,1,3,3-tetramethyldisiloxane (TMDS)/Fe(acac)(3) is reported here as a new method to obtain amines from aromatic nitro compounds. Amines are synthetized in a straightforward step and are isolated as hydrochloride salts with good to excellent yields. This system has shown a good selectivity toward aryl-chloride, aryl-bromide, ester, carboxylic acid, and cyano groups. The reduction of alkylnitro compounds was unfortunately not possible using this method, only a mixture of mono and dialkylated amine was obtained. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1971 / 1976

页数：6

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