Dramatic and Durable Responses to Romidepsin in Two Patients With the Lymphocytic Variant of Hypereosinophilic Syndrome

被引：3

作者：

Abbasi, Aleeza ^{[1
]}

Chung, Catherine ^{[2
]}

William, Basem M. ^{[1
]}

机构：

[1] Ohio State Univ, Wexner Med Ctr, Div Hematol, Columbus, OH 43210 USA

[2] Ohio State Univ, Wexner Med Ctr, Dept Internal Med, Dept Dermatol, Columbus, OH 43210 USA

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2020年 / 20卷 / 03期

关键词：

Histone deacetylase inhibitors; Hypereosinophilic syndrome; Romidepsin; Sezary syndrome; EOSINOPHILIC DISORDERS;

D O I：

10.1016/j.clml.2019.11.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lymphocytic variant of hypereosinophilic syndrome (L-HES) is a rare condition characterized by esosinophilia associated with the presence of clonal T-cells. L-HES has some overlapping clinical features with cutaneous T-cell lymphoma, especially Sezary syndrome. We report dramatic and durable responses to romidepsin, a histone deacetylase inhibitor currently approved for treatment of cutaneous T-cell lymphoma, in 2 patients with L-HES. Our observation further support the recent reports of common pathobiologic mechanisms between L-HES and Sezary syndrome. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：E128 / E130

页数：3

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