Prognostic evaluation of immunohistochemical profiles in diffuse large B-cell lymphoma: a Chinese study

被引:9
作者
Chen, Zi [1 ,2 ]
Du, Zunguo [1 ]
Chen, Jieqing [3 ]
Chen, Zhongqing [1 ,2 ]
Bao, Yun [1 ]
Tang, Feng [1 ]
机构
[1] Fudan Univ, Dept Pathol, Huashan Hosp, Shanghai 200040, Peoples R China
[2] Fudan Univ, Dept Hematol, Huashan Hosp, Shanghai 200040, Peoples R China
[3] Univ Texas MD Anderson Canc Ctr, Dept Melanoma, Houston, TX 77030 USA
关键词
Diffuse large B-cell lymphoma; Immunohistochemical profile; Survival analysis; NON-HODGKINS-LYMPHOMA; GERMINAL CENTER; EXPRESSION; CD5(+); IMMUNOPHENOTYPE; CLASSIFICATION; CHEMOTHERAPY; SURVIVAL; ORIGIN; IMPACT;
D O I
10.1007/s12032-010-9433-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Diffuse large B-cell lymphoma (DLBCL) has been classified into different prognostic subgroups using immunohistochemistry in Western populations. However, the applicability in Chinese patients of these subgroups was unclear. We collected 116 specimens and performed immunohistochemical staining for CD10, BCL-6, MUM1, CD138, and CD5, and the results were classified into subgroups according to 3 different algorithms. We then analyzed the subgroups' correlation to patient survival. Expression of CD10 and BCL-6 predicted favorable 5-year OS (70 and 62.5%, respectively) and PFS (64.3 and 61.5%, respectively) rates. In contrast, the expression of MUM1 predicted unfavorable 5-year OS (23.1%) and PFS (17.9%) rates and was also independent of other markers. All algorithms led to useful subclassifications. Using Hans' algorithm based on CD10, BCL-6, and MUM1, the non-germinal center (GC) subgroup (66.4%) had worse 5-year OS (29.8%) and PFS (26.7%) rates than did the GC subgroup. Likewise, using Muris' algorithm based on CD10 and MUM1, fewer non-GC cases (27%) showed poorer OS (20.3%) and PFS (16.2%) rates than did GC cases, an effect that was independent of both the International Prognostic Index, a clinical indicator, and treatment. It identified a subgroup with a high-risk of death and seemed to be applicable in our series. In conclusion, these algorithms can be used effectively in Chinese patients with DLBCL.
引用
收藏
页码:241 / 248
页数:8
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