A Two-Step, One-Pot Enzymatic Synthesis of 2-Substituted 1,3-Diols

被引：27

作者：

Kalaitzakis, Dimitris ^{[1
]}

Smonou, Ioulia ^{[1
]}

机构：

[1] Univ Crete, Dept Chem, Iraklion 71003, Crete, Greece

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 24期

关键词：

NADPH-DEPENDENT KETOREDUCTASES; LIPASE RESOLUTION PROTOCOL; CHEMOENZYMATIC SYNTHESIS; ASYMMETRIC-SYNTHESIS; CASCADE REACTIONS; REDUCTION; ACID; COMBINATION; DERIVATIVES; CATALYSIS;

D O I：

10.1021/jo101519t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A biocatalytic cascade reaction was designed for the stereoselective synthesis of optically pure 2-alkyl-1,3-diols employing two enzymes. The cascade process consists of two consecutive steps: a stereoselective diketone reduction and a hydroxy ketone reduction. Chiral diols were formed by the addition of ketoreductases in the same vessel, in high stereoselectivity and chemical yield, without the isolation of the intermediate beta-hydroxy ketones.

引用

页码：8658 / 8661

页数：4

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