5-HT2AR and BDNF gene variants in eating disorders susceptibility

被引：21

作者：

Ceccarini, M. Rachele ^{[1
]}

Tasegian, Anna ^{[1
]}

Franzago, Marica ^{[2
,3
]}

Patria, F. Filomena ^{[1
]}

Albi, Elisabetta ^{[1
]}

Codini, Michela ^{[1
]}

Conte, Carmela ^{[1
]}

Bertelli, Matteo ^{[4
]}

Dalla Ragione, Laura ^{[5
]}

Stuppia, Liborio ^{[3
,6
]}

Beccari, Tommaso ^{[1
]}

机构：

[1] Univ Perugia, Dept Pharmaceut Sci, Via Fabretti, Perugia, Italy

[2] Univ G DAnnunzio, Sch Med & Hlth Sci, Dept Med & Aging, Chieti, Italy

[3] Univ G DAnnunzio, Aging & Translat Med Res Ctr CeSI MeT, Chieti, Italy

[4] MAGI Euregio, Non Profit Genet Testing Lab, Res Unit, Bolzano, Italy

[5] Univ Campus Biomedico, Dipartimento Sci & Tecnol Uomo & Ambiente, Rome, Italy

[6] Univ G DAnnunzio, Sch Med & Hlth Sci, Dept Psychol Hlth & Terr Sci, Chieti, Italy

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2020年 / 183卷 / 03期

关键词：

5-HT2AR; anorexia nervosa; BDNF; binge eating; bulimia nervosa; NEUROTROPHIC FACTOR VAL66MET; GENOME-WIDE ASSOCIATION; SEROTONIN RECEPTOR 2A; ANOREXIA-NERVOSA; BULIMIA-NERVOSA; PROMOTER POLYMORPHISM; HTR2A; FAMILY; TWIN; HERITABILITY;

D O I：

10.1002/ajmg.b.32771

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.

引用

页码：155 / 163

页数：9

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