Host gut resistome in Gulf War chronic multisymptom illness correlates with persistent inflammation

被引：5

作者：

Bose, Dipro ^{[1
]}

Chatterjee, Somdatta ^{[1
]}

Older, Ethan ^{[2
]}

Seth, Ratanesh ^{[1
]}

Janulewicz, Patricia ^{[3
]}

Saha, Punnag ^{[1
]}

Mondal, Ayan ^{[1
]}

Carlson, Jeffrey M. ^{[3
]}

Decho, Alan W. ^{[1
]}

Sullivan, Kimberly ^{[3
]}

Klimas, Nancy ^{[4
]}

Lasley, Stephen ^{[5
]}

Li, Jie ^{[2
]}

Chatterjee, Saurabh ^{[1
,6
]}

机构：

[1] Univ South Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Environm Hlth & Dis Lab, Columbia, SC 29208 USA

[2] Univ South Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

[3] Boston Univ, Dept Environm Hlth, Sch Publ Hlth, Boston, MA 02215 USA

[4] Nova Southeastern Univ, Dept Clin Immunol, Ft Lauderdale, FL 33314 USA

[5] Univ Illinois, Dept Canc Biol & Pharmacol, Coll Med, Peoria, IL USA

[6] Columbia VA Med Ctr, Columbia, SC 29209 USA

来源：

COMMUNICATIONS BIOLOGY | 2022年 / 5卷 / 01期

基金：

美国国家科学基金会;

关键词：

FECAL MICROBIOTA TRANSPLANTATION; ANTIBIOTIC-RESISTANCE GENES; CD-HIT; VETERANS; HEALTH; VANCOMYCIN; PREVALENCE; INSTRUMENT; CHALLENGES; EXPOSURES;

D O I：

10.1038/s42003-022-03494-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans' with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal healthy controls. The altered resistome and gene signature is correlated with mouse serum IL-6 levels. Altered resistome in mice also is correlated strongly with intestinal inflammation, decreased synaptic plasticity, reversible with fecal microbiota transplant (FMT). The results reported might help in understanding the risks to treating hospital acquired infections in this population. Analysis of fecal samples from patients and mice, shows that chronic multisymptom illness which affects a subsection of elderly and war Veterans, is associated with alteration in genes related to antibiotic resistance.

引用

页数：15

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