Highly stereoselective and practical synthesis of a key intermediate for 1-beta-methylcarbapenems

被引：6
|
作者：
Yamanaka, T
Seki, M
Kuroda, T
Ohmizu, H
Iwasaki, T
机构：
[1] TANABE SEIYAKU CO LTD,PHARMACEUT DEV RES LAB,YODOGAWA KU,OSAKA 532,JAPAN
[2] TANABE SEIYAKU CO LTD,LEAD OPTIMIZAT RES LAB,YODOGAWA KU,OSAKA 532,JAPAN
[3] TANABE SEIYAKU CO LTD,RES DEV PLANNING DIV,YODOGAWA KU,OSAKA 532,JAPAN
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 28期
关键词：
D O I：
10.1016/0040-4039(96)00980-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The sodium enolate generated from N-propionyl-2, 2-diethyl-1, 3-benzoxazinone 2b was allowed to react with acetoxyazetidinone 3 to give an adduct 4b in 87% yield with virtually complete beta-selectivity which was transformed by simple hydrolysis into the optically pure azetidinone-4-isopropionic acid derivative 5, a key intermediate of 1-beta-methylcarbapenems. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：4967 / 4968
页数：2
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