Plasmonic Copper Sulfide Nanocrystals Exhibiting Near-Infrared Photothermal and Photodynamic Therapeutic Effects

被引:560
作者
Wang, Shunhao [1 ,3 ]
Riedinger, Andreas [2 ,4 ]
Li, Hongbo [4 ]
Fu, Changhui [1 ]
Liu, Huiyu [1 ]
Li, Linlin [1 ]
Liu, Tianlong [1 ]
Tan, Longfei [1 ]
Barthel, Markus J. [4 ]
Pugliese, Giammarino [4 ]
De Donato, Francesco [4 ]
D'Abbusco, Marco Scotto [4 ]
Meng, Xianwei [1 ]
Manna, Liberato [4 ]
Meng, Huan [5 ]
Pellegrino, Teresa [4 ]
机构
[1] Chinese Acad Sci, Tech Inst Phys & Chem, Res Ctr Micro & Nano Mat & Technol, Lab Controllable Preparat & Applicat Nanomat, Beijing 100190, Peoples R China
[2] ETH, Opt Mat Engn Lab, CH-8092 Zurich, Switzerland
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Ist Italiano Tecnol, I-16163 Genoa, Italy
[5] Univ Calif Los Angeles, Dept Med, Div NanoMed, Los Angeles, CA 90095 USA
基金
中国国家自然科学基金;
关键词
copper sulfide nanocrystals; near-infrared light; photothermal therapy; photodynamic therapy; HEAT CONVERSION EFFICIENCY; IN-VIVO; GOLD NANOSHELLS; SILICA NANORATTLES; ASCORBIC-ACID; RESONANCE; NANOPARTICLES; OXYGEN; ABSORPTION; DELIVERY;
D O I
10.1021/nn506687t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Recently, plasmonic copper sulfide (Cu2-xS) nanocrystals (NCs) have attracted much attention as materials for photothermal therapy (PTT). Previous reports have correlated photoinduced cell death to the photothermal heat mechanism of these NCs, and no evidence of their photodynamic properties has been reported yet. Herein we have prepared physiologically stable near-infrared (NIR) plasmonic copper sulfide NCs and analyzed their photothermal and photodynamic properties, including therapeutic potential in cultured melanoma cells and a murine melanoma model. Interestingly, we observe that, besides a high PTT efficacy, these copper sulfide NCs additionally possess intrinsic NIR induced photodynamic activity, whereupon they generate high levels of reactive oxygen species. Furthermore, in vitro and in vivo acute toxic responses of copper sulfide NCs were also elicited. This study highlights a mechanism of NIR light induced cancer therapy, which could pave the way toward more effective nanotherapeutics.
引用
收藏
页码:1788 / 1800
页数:13
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