Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

被引：187

作者：

Corbett, Kizzmekia S. ^{[1
,9
]}

Nason, Martha C. ^{[2
]}

Flach, Britta ^{[1
]}

Gagne, Matthew ^{[1
]}

O' Connell, Sarah ^{[1
]}

Johnston, Timothy S. ^{[1
]}

Shah, Shruti N. ^{[1
]}

Edara, Venkata Viswanadh ^{[3
]}

Floyd, Katharine ^{[3
]}

Lai, Lilin ^{[3
]}

McDanal, Charlene ^{[4
]}

Francica, Joseph R. ^{[1
,10
]}

Flynn, Barbara ^{[1
]}

Wu, Kai ^{[5
]}

Choi, Angela ^{[5
]}

Koch, Matthew ^{[5
]}

Abiona, Olubukola M. ^{[1
]}

Werner, Anne P. ^{[1
]}

Moliva, Juan, I ^{[1
]}

Andrew, Shayne F. ^{[1
]}

Donaldson, Mitzi M. ^{[1
]}

Fintzi, Jonathan ^{[1
]}

Flebbe, Dillon R. ^{[1
]}

Lamb, Evan ^{[1
]}

Noe, Amy T. ^{[1
]}

Nurmukhambetova, Saule T. ^{[1
]}

Provost, Samantha J. ^{[1
]}

Cook, Anthony ^{[6
]}

Dodson, Alan ^{[6
]}

Faudree, Andrew ^{[6
]}

Greenhouse, Jack ^{[6
]}

Kar, Swagata ^{[6
]}

Pessaint, Laurent ^{[6
]}

Porto, Maciel ^{[6
]}

Steingrebe, Katelyn ^{[6
]}

Valentin, Daniel ^{[6
]}

Zouantcha, Serge ^{[6
]}

Bock, Kevin W. ^{[7
]}

Minai, Mahnaz ^{[7
]}

Nagata, Bianca M. ^{[7
]}

van de Wetering, Renee ^{[1
]}

Boyoglu-Barnum, Seyhan ^{[1
]}

Leung, Kwanyee ^{[1
]}

Shi, Wei ^{[1
]}

Yang, Eun Sung ^{[1
]}

Zhang, Yi ^{[1
]}

Todd, John-Paul M. ^{[1
]}

Wang, Lingshu ^{[1
]}

Alvarado, Gabriela S. ^{[1
]}

Andersen, Hanne ^{[6
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[2] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA

[3] Emory Univ, Ctr Childhood Infect & Vaccines Childrens Healthc, Emory Vaccine Ctr, Dept Pediat,Dept Microbiol & Immunol, Atlanta, GA 30322 USA

[4] Duke Univ, Dept Surg, Med Ctr, Durham, NC 27708 USA

[5] Moderna Inc, Cambridge, MA 02139 USA

[6] Bioqual Inc, Rockville, MD 20850 USA

[7] NIAID, Infect Dis Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[8] Dept Microbiol & Immunol, Atlanta, GA 30329 USA

[9] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02124 USA

[10] AstraZeneca, Gaithersburg, MD 20878 USA

来源：

SCIENCE | 2021年 / 373卷 / 6561期

关键词：

DIELECTRIC LASER ACCELERATION; SUB-RELATIVISTIC ELECTRONS; OPTICAL-EXCITATIONS; QUANTUM WALKS; LIGHT; NEUTRALIZATION; IMMUNIZATION; GENERATION; INFECTION; COVID-19;

D O I：

10.1126/science.abj0299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 mg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of anti-S antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273-induced immunoglobulin G to naive hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine-induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.

引用

页码：1325 / +

页数：55

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