Copper-catalyzed one-pot N-alkenylation and N-alkylation of amides: an efficient synthesis of substituted 2,3-dihydropyrroles

被引：27
作者：
Zhou, Xiaobo
Zhang, Huimin
Yuan, Jiwei
Mai, Lugen
Li, Yanzhong
机构：
[1] E China Normal Univ, Dept Chem, Shanghai 200062, Peoples R China
[2] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 40期
基金：
中国国家自然科学基金;
关键词：
copper catalyst; N-alkenylation; N-alkylation; amides; dihydropyrroles;
D O I：
10.1016/j.tetlet.2007.07.221
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel copper-catalyzed synthesis of substituted 2,3-dihydropyrroles via one-pot N-alkenylation and N-alkylation of amides with 1.4-diiodobut-1-ene derivatives has been developed. The reactions proceed in good to high yields using CuI as the catalyst, K2CO3 as the base, and rac-trans-N,N'-dimethylcycloliexane-1,2-diamine as the ligand. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：7236 / 7239
页数：4
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