Stem Cell Therapy: Pieces of the Puzzle

被引：23

作者：

Schoenhard, John A. ^{[1
,2
]}

Hatzopoulos, Antonis K. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2010年 / 3卷 / 01期

关键词：

Heart Failure; Myocardial Infarction; Stem Cells; Cell Therapy; Cardiac Regeneration; ENDOTHELIAL PROGENITOR CELLS; INTEGRIN-LINKED KINASE; BONE-MARROW-CELLS; ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; IMPROVES CARDIAC-FUNCTION; LEFT-VENTRICULAR FUNCTION; GROWTH-FACTOR-I; SMOOTH-MUSCLE; FUNCTIONAL IMPROVEMENT;

D O I：

10.1007/s12265-009-9148-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute ischemic injury and chronic cardiomyopathies can cause irreversible loss of cardiac tissue leading to heart failure. Cellular therapy offers a new paradigm for treatment of heart disease. Stem cell therapies in animal models show that transplantation of various cell preparations improves ventricular function after injury. The first clinical trials in patients produced some encouraging results, despite limited evidence for the long-term survival of transplanted cells. Ongoing research at the bench and the bedside aims to compare sources of donor cells, test methods of cell delivery, improve myocardial homing, bolster cell survival, and promote cardiomyocyte differentiation. This article reviews progress toward these goals.

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页码：49 / 60

页数：12

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