GMI ablates cancer stemness and cisplatin resistance in oral carcinomas stem cells through IL-6/Stat3 signaling inhibition

被引：18

作者：

Wang, Tung Yuan ^{[1
]}

Yu, Cheng-Chia ^{[1
,2
,3
]}

Hsieh, Pei-Ling ^{[3
]}

Liao, Yi-Wen ^{[1
]}

Yu, Chuan-Hang ^{[1
,2
]}

Chou, Ming-Yung ^{[1
,2
]}

机构：

[1] Chung Shan Med Univ, Sch Dent, Taichung, Taiwan

[2] Chung Shan Med Univ Hosp, Dept Dent, Taichung, Taiwan

[3] Chung Shan Med Univ, Inst Oral Sci, Taichung, Taiwan

来源：

ONCOTARGET | 2017年 / 8卷 / 41期

关键词：

oral squamous cell carcinomas; immunomodulatory protein GMI; cancer stem cells; chemoresistance; IL-6/Stat3; signaling; NF-KAPPA-B; IMMUNOMODULATORY PROTEIN; GANODERMA-MICROSPORUM; HEAD; STAT3; PATHWAY; IDENTIFICATION; EXPRESSION; INDUCTION; AUTOPHAGY;

D O I：

10.18632/oncotarget.19711

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) have been identified to exert tumor-initiating ability, resulting in the recurrence, metastasis and chemoresistance of oral squamous cell carcinomas. In the present study, we showed that GMI, an immunomodulatory protein from Ganoderma microsporum, induc ed a cytotoxic effect in oral carcinomas stem cells (OCSCs). Treatment of GMI dose-dependently inhibited the expression of CSC markers, including ALDH1 activity and CD44 positivity. Moreover, GMI suppressed the self-renewal property, colony formation, migration, and invasion abilities as well as potentiated chemo-sensitivity in OCSCs. Our results suggested that the tumor suppressive effect of GMI was mediated through inhibition of IL-6/Stat3 signaling pathway. Furthermore, tumor growth was reduced in mice bearing xenograft tumors after oral administration of GMI. Taken together, we demonstrated the anti-CSC effect of GMI in oral cancer and GMI may serve as a natural cisplatin adjuvant to prevent cancer recurrence.

引用

页码：70422 / 70430

页数：9

共 38 条

[1] Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt [J].