LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204

被引：2

作者：

Li, Jipeng ^{[1
]}

Wang, Jianhua ^{[1
]}

Chen, Yin ^{[1
]}

Li, Shanfeng ^{[1
]}

Jin, Mingwei ^{[1
]}

Wang, Huaying ^{[2
]}

Chen, Zhe ^{[1
]}

Yu, Wanjun ^{[2
]}

机构：

[1] Yinzhou Peoples Hosp, Dept Cent Lab, Ningbo 315040, Zhejiang, Peoples R China

[2] Yinzhou Peoples Hosp, Dept Resp & Crit Care Med, 251 East Baizhang Rd, Ningbo 315040, Zhejiang, Peoples R China

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2016年 / 6卷 / 05期

关键词：

Lung adenocarcinoma; MALAT1; miR-204; SLUG; LONG NONCODING RNA; EPITHELIAL-MESENCHYMAL TRANSITION; RENAL-CELL CARCINOMA; CANCER CELLS; SLUG; METASTASIS; PROMOTES; INVASION; EXPRESSION; REGULATOR;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204. In summary we unveil a branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma.

引用

页码：1099 / +

页数：10

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