Strong Detrimental Effect of a Minute Enantiomeric Impurity of a Chiral Selector on the Enantioselectivity Factor

被引：23

作者：

Levkin, Pavel A. ^{[2
]}

Maier, Norbert M. ^{[1
]}

Schurig, Volker ^{[2
]}

Lindner, Wolfgang ^{[1
]}

机构：

[1] Univ Vienna, Inst Analyt Chem, A-1090 Vienna, Austria

[2] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 42期

关键词：

chiral chromatography; chiral selectors; enantiomer separation; enantioselectivity; liquid chromatography; SEPARATION; RECOGNITION;

D O I：

10.1002/anie.201002215

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Without a trace? The higher the enantioselectivity of a chiral selector, the more it is sensitive to enantiomeric impurities. Therefore, the enantiomeric purity of a chiral selector affects the enantioseparation factor - (see picture). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7742 / 7744

页数：3

共 11 条

[1]

BEITLER U, 1976, CHROMATOGR A, V123, P149

[2] SEPARATION OF ENANTIOMERIC COMPOUNDS USING CHIRAL HPLC SYSTEMS - A BRIEF REVIEW OF GENERAL-PRINCIPLES, ADVANCES, AND DEVELOPMENT TRENDS [J].

DAVANKOV, VA .

CHROMATOGRAPHIA, 1989, 27 (9-10) :475-482

[3] Separation of Cinchona alkaloids on a novel strong cation-exchange-type chiral stationary phase-comparison with commercially available strong cation exchanger and reversed-phase packing materials [J].

Hoffmann, Christian V. ;

Laemmerhofer, Michael ;

Lindner, Wolfgang .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2009, 393 (04) :1257-1265

[4]

Lämmerhofer M, 2008, ADV CHROMATOGR, V46, P1

[5]

LAMMERHOFER M, 1996, CHROMATOGR A, V741, P33

[6]

LEVKIN PA, 2008, CHROMATOGR A, V1184, P309

[7]

Maier NM, 1999, CHIRALITY, V11, P522, DOI 10.1002/(SICI)1520-636X(1999)11:7<522::AID-CHIR2>3.3.CO

[8]

2-L

[9] Some thoughts on the coupling of dissimilar chiral columns or the mixing of chiral stationary phases for the separation of enantiomers [J].

Pirkle, WH ;

Welch, CJ .

JOURNAL OF CHROMATOGRAPHY A, 1996, 731 (1-2) :322-326

[10] Elaborate treatment of retention in chemoselective chromatography-The retention increment approach and non-linear effects [J].

Schurig, Volker .

JOURNAL OF CHROMATOGRAPHY A, 2009, 1216 (10) :1723-1736

← 1 2 →