Host-microbiota interactions and adaptive immunity

被引：64

作者：

McCoy, Kathy D. ^{[1
]}

Ronchi, Francesca ^{[2
]}

Geuking, Markus B. ^{[3
]}

机构：

[1] Univ Calgary, Calvin Phoebe & Joan Snyder Inst Chron Dis, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB, Canada

[2] Univ Hosp, UVCM, Dept Clin Res DKF, Maurice Muller Labs, Bern, Switzerland

[3] Univ Calgary, Cumming Sch Med, Phoebe & Joan Snyder Inst Chron Dis, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada

来源：

IMMUNOLOGICAL REVIEWS | 2017年 / 279卷 / 01期

关键词：

antibodies; B cell lineages and subsets; IgA; microbiota; mucosal tissues; T cell lineages and subsets; REGULATORY T-CELLS; SEGMENTED FILAMENTOUS BACTERIA; GUT MICROBIOTA; IGA; COLONIZATION; HOMEOSTASIS; RESPONSES; PROMOTE; DIFFERENTIATION; MAINTENANCE;

D O I：

10.1111/imr.12575

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

All mucosal surfaces are colonized with a vast number of microbes, which are essential for stimulating and regulating the immune system. While intrinsic and innate mechanisms exist to promote a strong barrier between the microbiota and the host to ensure compartmentalization, the microbiota is also able to induce robust adaptive immunity. In this review, we discuss the interplay between the microbiota and the adaptive immune system, with a focus on the induction of mucosal and systemic antibody responses and newly defined roles of maternal antibodies. We also highlight recent studies that aim to decipher microbial antigen-specificity of the T-cell compartment.

引用

页码：63 / 69

页数：7

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