Effect of the selective adenosine A1-receptor antagonist KW-3902 on tubuloglomerular feedback in radiocontrast-media-induced nephropathy in rats with chronic nitric oxide deficiency

被引：6
|
作者：
Yao, KZ
Heyne, N
Osswald, H
机构：
[1] Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Inst, Durg Dev Res Labs, Shizuoka 4118731, Japan
[2] Univ Tubingen, Fac Med, Dept Pharmacol, D-72074 Tubingen, Germany
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 84卷 / 03期
关键词：
contrast media; adenosine; tubuloglomerular feedback;
D O I：
10.1254/jjp.84.347
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To study the possible mechanism of renoprotective effects of adenosine A(1)-receptor antagonist against radiocontrast media (RCM)-induced nephropathy, we investigated the effects of adenosine A(1)-receptor antagonist on tubuloglomerular feedback (TGF) activity prior to and following application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats was significantly enhanced compared with that in normal rats. After RCM application, the enhanced TGF was continued. A selective adenosine A(1)-receptor antagonist, KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), inhibited the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in chronic NO-depleted rats. Renoprotective effects by adenosine antagonists could be partly due to an inhibition of TGF via the blockade of the adenosine A(1)-receptor.
引用
收藏
页码：347 / 350
页数：4
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