The Emerging Clinical Application of m6A RNA Modification in Inflammatory Bowel Disease and Its Associated Colorectal Cancer

被引：40

作者：

Xu, Xinwei ^{[1
]}

Huang, Jintu ^{[2
]}

Ocansey, Dickson Kofi Wiredu ^{[1
,3
]}

Xia, Yuxuan ^{[1
]}

Zhao, Zihan ^{[1
]}

Xu, Zhiwei ^{[1
]}

Yan, Yongmin ^{[1
]}

Zhang, Xu ^{[1
]}

Mao, Fei ^{[1
]}

机构：

[1] Jiangsu Univ, Dept Clin Lab Diagnost, Key Lab Med Sci & Lab Med Jiangsu Prov, Sch Med, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Nantong Univ, Clin Lab Dept, Peoples Hosp Danyang, Affiliated Danyang Hosp, Zhenjiang 212300, Jiangsu, Peoples R China

[3] Univ Cape Coast, Dept Clin Lab Diagnost, Directorate Univ Hlth Serv, Cape Coast, Ghana

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2021年 / 14卷

基金：

中国国家自然科学基金;

关键词：

N6-methyladenosine; inflammatory bowel disease; colorectal cancer; non-coding RNA; intestinal mucosal immunity; MESSENGER-RNA; NUCLEAR-RNA; M(6)A MODIFICATION; METHYLATION; PATTERNS; FTO; DEMETHYLASE; WIDESPREAD; METABOLISM; EXPRESSION;

D O I：

10.2147/JIR.S320449

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Methylation, first proposed in DNAs, but later found in RNAs, serves as one of the most widespread epigenetic modifications in eukaryotes, where N6-methyladenosine (m6A) modification has been found to play an important role in a variety of cancers including colorectal cancer (CRC). Under the action of various enzymes and proteins, the regulatory role of m6A in RNAs and immune cells has also been gradually realized. This paper reviews the general biogenesis and effects of m6A, and its emerging crucial role in intestinal mucosal immunity via the regulation of RNAs and immune cells, and thus closely related to the occurrence and development of inflammatory bowel disease (IBD) and CRC. m6A-related genes and regulatory factors are expected to be potential predictive markers and therapeutic targets.

引用

页码：3289 / 3306

页数：18

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