Extracorporeal Shock Wave Treatment (ESWT) enhances the in vitro-induced differentiation of human tendon-derived stem/progenitor cells (hTSPCs)

被引：32

作者：

Leone, Laura ^{[1
]}

Raffa, Salvatore ^{[1
,4
]}

Vetrano, Mario ^{[2
]}

Ranieri, Danilo ^{[1
]}

Malisan, Florence ^{[3
]}

Scrofani, Cristina ^{[1
]}

Vulpiani, Maria Chiara ^{[2
]}

Ferretti, Andrea ^{[2
]}

Torrisi, Maria Rosaria ^{[1
,4
]}

Visco, Vincenzo ^{[1
,4
]}

机构：

[1] Univ Roma La Sapienza, Dept Clin & Mol Med, Fac Med & Psychol, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Orthoped & Traumatol, Fac Med & Psychol, St Andrea Hosp, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[3] Univ Roma Tor Vergata, Dept Biomed & Prevent, Lab Signal Transduct, Rome, Italy

[4] St Andrea Hosp, Cellular Diagnost Unit, Rome, Italy

来源：

ONCOTARGET | 2016年 / 7卷 / 06期

关键词：

differentiation; tendon; stem cells; healing; ESWT; Pathology Section; MESENCHYMAL STEM-CELLS; PROGENITOR CELLS; BONE-MARROW; TISSUE; REPAIR; DEFECT; SCLERAXIS; TDSCS; RAT;

D O I：

10.18632/oncotarget.7064

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extracorporeal shock wave therapy (ESWT) is a non-invasive and innovative technology for the management of specific tendinopathies. In order to elucidate the ESWT-mediated clinical benefits, human Tendon-derived Stem/Progenitor cells (hTSPCs) explanted from 5 healthy semitendinosus (ST) and 5 ruptured Achilles (AT) tendons were established. While hTSPCs from the two groups showed similar proliferation rates and stem cell surface marker profiles, we found that the clonogenic potential was maintained only in cells derived from healthy donors. Interestingly, ESWT significantly accelerated hTSPCs differentiation, suggesting that the clinical benefits of ESWT may be ascribed to increased efficiency of tendon repair after injury.

引用

页码：6410 / 6423

页数：14

共 43 条

[1] Anti-inflammatory cytokine profile in early human tendon repair [J].

Ackermann, P. W. ;

Domeij-Arverud, E. ;

Leclerc, P. ;

Amoudrouz, P. ;

Nader, G. A. .

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 2013, 21 (08) :1801-1806

[2] Exploring the Application of Stem Cells in Tendon Repair and Regeneration [J].

Ahmad, Zafar ;

Wardale, John ;

Brooks, Roger ;

Henson, Fran ;

Noorani, Ali ;

Rushton, Neil .

ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 2012, 28 (07) :1018-1029

[3]

[Anonymous], 2014, COCHRANE DATABASE SY

[4] Tendon Progenitor Cells in Injured Tendons Have Strong Chondrogenic Potential: The CD105-Negative Subpopulation Induces Chondrogenic Degeneration [J].

Asai, Shuji ;

Otsuru, Satoru ;

Candela, Maria Elena ;

Cantley, Leslie ;

Uchibe, Kenta ;

Hofmann, Ted J. ;

Zhang, Kairui ;

Wapner, Keith L. ;

Soslowsky, Louis J. ;

Horwitz, Edwin M. ;

Enomoto-Iwamoto, Motomi .

STEM CELLS, 2014, 32 (12) :3266-3277

[5] Indirect Co-Culture with Tendons or Tenocytes Can Program Amniotic Epithelial Cells towards Stepwise Tenogenic Differentiation [J].

Barboni, Barbara ;

Curini, Valentina ;

Russo, Valentina ;

Mauro, Annunziata ;

Di Giacinto, Oriana ;

Marchisio, Marco ;

Alfonsi, Melissa ;

Mattioli, Mauro .

PLOS ONE, 2012, 7 (02)

[6] Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche [J].

Bi, Yanming ;

Ehirchiou, Driss ;

Kilts, Tina M. ;

Inkson, Colette A. ;

Embree, Mildred C. ;

Sonoyama, Wataru ;

Li, Li ;

Leet, Arabella I. ;

Seo, Byoung-Moo ;

Zhang, Li ;

Shi, Songtao ;

Young, Marian F. .

NATURE MEDICINE, 2007, 13 (10) :1219-1227

[7]

Catalano MG, 2014, J TISSUE ENG REGENER

[8] Recruitment of mesenchymal stem cells and expression of TGF-β1 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats [J].

Chen, YJ ;

Wurtz, T ;

Wang, CJ ;

Kuo, YR ;

Yang, KD ;

Huang, HC ;

Wang, FS .

JOURNAL OF ORTHOPAEDIC RESEARCH, 2004, 22 (03) :526-534

[9]

CSERJESI P, 1995, DEVELOPMENT, V121, P1099

[10] Intrinsic differentiation potential of adolescent human tendon tissue: an in-vitro cell differentiation study [J].

de Mos, Marieke ;

Koevoet, Wendy J. L. M. ;

Jahr, Holger ;

Verstegen, Monique M. A. ;

Heijboer, Marinus P. ;

Kops, Nicole ;

Van Leeuwen, Johannes P. T. M. ;

Weinans, Harrie ;

Verhaar, Jan A. N. ;

van Osch, Gerjo J. V. M. .

BMC MUSCULOSKELETAL DISORDERS, 2007, 8

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