Rett mutations attenuate phase separation of MeCP2

被引:24
|
作者
Fan, Chunyan [1 ]
Zhang, Honglian [1 ]
Fu, Liangzheng [1 ,2 ]
Li, Yuejiao [1 ,2 ]
Du, Yi [1 ,2 ]
Qiu, Zilong [2 ,3 ,4 ]
Lu, Falong [1 ,2 ,5 ]
机构
[1] Chinese Acad Sci, State Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
[4] Chinese Acad Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China
[5] Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100101, Peoples R China
基金
中国国家自然科学基金;
关键词
SELF-RENEWAL; BINDING; PROTEIN; SEQUENCE; NEURONS; DNA;
D O I
10.1038/s41421-020-0172-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [41] Neuroanatomy in mouse models of Rett syndrome is related to the severity of Mecp2 mutation and behavioral phenotypes
    Allemang-Grand, Rylan
    Ellegood, Jacob
    Noakes, Leigh Spencer
    Ruston, Julie
    Justice, Monica
    Nieman, Brian J.
    Lerch, Jason P.
    MOLECULAR AUTISM, 2017, 8
  • [42] Analysis of the Parental Origin of De Novo MECP2 Mutations and X Chromosome Inactivation in 24 Sporadic Patients With Rett Syndrome in China
    Zhu, Xingwang
    Li, Meirong
    Pan, Hong
    Bao, Xinhua
    Zhang, Jingjing
    Wu, Xiru
    JOURNAL OF CHILD NEUROLOGY, 2010, 25 (07) : 842 - 848
  • [43] MECP2 mutations in Czech patients with Rett syndrome and Rett-like phenotypes: novel mutations, genotype-phenotype correlations and validation of high-resolution melting analysis for mutation scanning
    Zahorakova, Daniela
    Lelkova, Petra
    Gregor, Vladimir
    Magner, Martin
    Zeman, Jiri
    Martasek, Pavel
    JOURNAL OF HUMAN GENETICS, 2016, 61 (07) : 617 - 625
  • [44] Novel Mutation in the MECP2 Gene Identified in a Group of Rett Syndrome Patients from Ukraine
    Chernushyn, S.
    Gulkovskyi, R.
    Livshits, L.
    CYTOLOGY AND GENETICS, 2018, 52 (04) : 294 - 298
  • [45] Fluoxetine rescues rotarod motor deficits in Mecp2 heterozygous mouse model of Rett syndrome via brain serotonin
    Villani, Claudia
    Sacchetti, Giuseppina
    Carli, Mirjana
    Invernizzi, Roberto W.
    NEUROPHARMACOLOGY, 2020, 176
  • [46] Systemic Delivery of MeCP2 Rescues Behavioral and Cellular Deficits in Female Mouse Models of Rett Syndrome
    Garg, Saurabh K.
    Lioy, Daniel T.
    Cheval, Helene
    McGann, James C.
    Bissonnette, John M.
    Murtha, Matthew J.
    Foust, Kevin D.
    Kaspar, Brian K.
    Bird, Adrian
    Mandel, Gail
    JOURNAL OF NEUROSCIENCE, 2013, 33 (34) : 13612 - 13620
  • [47] Phenotypic variability in two infants sharing the same MECP2 mutation: evidence of chromosomal rearrangements and high sister-chromatid exchange levels in Rett syndrome
    Kharrat, Marwa
    Hsairi, Ines
    Doukali, Hajer
    Fendri-Kriaa, Nourhene
    Kammoun, Hassen
    Ammar-keskes, Leila
    Triki, Chahnez
    Fakhfakh, Faiza
    ACTA NEUROLOGICA BELGICA, 2017, 117 (01) : 251 - 258
  • [48] Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations
    Mok, Rebecca S. F.
    Zhang, Wenbo
    Sheikh, Taimoor, I
    Pradeepan, Kartik
    Fernandes, Isabella R.
    DeJong, Leah C.
    Benigno, Gabriel
    Hildebrandt, Matthew R.
    Mufteev, Marat
    Rodrigues, Deivid C.
    Wei, Wei
    Piekna, Alina
    Liu, Jiajie
    Muotri, Alysson R.
    Vincent, John B.
    Muller, Lyle
    Martinez-Trujillo, Julio
    Salter, Michael W.
    Ellis, James
    TRANSLATIONAL PSYCHIATRY, 2022, 12 (01)
  • [49] MeCP2 as an Activator of Gene Expression
    Horvath, Patricia M.
    Monteggia, Lisa M.
    TRENDS IN NEUROSCIENCES, 2018, 41 (02) : 72 - 74
  • [50] The yin and yang of MeCP2 phosphorylation
    Chao, Hsiao-Tuan
    Zoghbia, Huda Y.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (12) : 4577 - 4578