Rett mutations attenuate phase separation of MeCP2

被引:24
|
作者
Fan, Chunyan [1 ]
Zhang, Honglian [1 ]
Fu, Liangzheng [1 ,2 ]
Li, Yuejiao [1 ,2 ]
Du, Yi [1 ,2 ]
Qiu, Zilong [2 ,3 ,4 ]
Lu, Falong [1 ,2 ,5 ]
机构
[1] Chinese Acad Sci, State Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 200031, Peoples R China
[4] Chinese Acad Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai 200031, Peoples R China
[5] Chinese Acad Sci, Innovat Acad Seed Design, Beijing 100101, Peoples R China
基金
中国国家自然科学基金;
关键词
SELF-RENEWAL; BINDING; PROTEIN; SEQUENCE; NEURONS; DNA;
D O I
10.1038/s41421-020-0172-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页数:4
相关论文
共 50 条
  • [31] Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2
    Yang, Kan
    Cheng, Cheng
    Yuan, Yiting
    Zhang, Yuefang
    Shan, Shifang
    Qiu, Zilong
    NEUROSCIENCE BULLETIN, 2023, 39 (02) : 297 - 302
  • [32] Variant Profile of MECP2 Gene in Sri Lankan Patients with Rett Syndrome
    Hettiarachchi, D.
    Neththikumara, N. F.
    Pathirana, B. A. P. S.
    Dissanayake, V. H. W.
    JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2020, 50 (01) : 118 - 126
  • [33] R306X Mutation in the MECP2 Gene Causes an Atypical Rett Syndrome in a Moroccan Patient: A Case Report
    Bouzroud, Wafaa
    Tazzite, Amal
    Berrada, Sarah
    Gazzaz, Bouchaib
    Dehbi, Hind
    CLINICAL PATHOLOGY, 2022, 15
  • [34] A case of a Tunisian Rett patient with a novel double-mutation of the MECP2 gene
    Fendri-Kriaa, Nourhene
    Hsairi, Ines
    Kifagi, Chamseddine
    Ellouze, Emna
    Mkaouar-Rebai, Emna
    Triki, Chahnez
    Fakhfakh, Faiza
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 409 (02) : 270 - 274
  • [35] Case Report: A Novel Mutation in the MECP2 Gene in a Korean Patient with Rett Syndrome
    Lee, Eun Young
    Chung, Hee-Jung
    Ki, Chang-Seok
    Yoo, Jong-Ha
    Choi, Jong Rak
    ANNALS OF CLINICAL AND LABORATORY SCIENCE, 2011, 41 (01) : 93 - 96
  • [36] Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
    Tropea, Daniela
    Giacometti, Emanuela
    Wilson, Nathan R.
    Beard, Caroline
    McCurry, Cortina
    Fu, Dong Dong
    Flannery, Ruth
    Jaenisch, Rudolf
    Sur, Mriganka
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (06) : 2029 - 2034
  • [37] Identification and characterization of novel sequence variations in MECP2 gene in Rett syndrome patients
    Monnerat, Leila Schuindt
    Moreira, Aline dos Santos
    Viana Alves, Maria Carolina
    Bonvicino, Cibele Rodrigues
    Vargas, Fernando Regla
    BRAIN & DEVELOPMENT, 2010, 32 (10) : 843 - 848
  • [38] Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies
    Sandweiss, Alexander J.
    Brandt, Vicky L.
    Zoghbi, Huda Y.
    LANCET NEUROLOGY, 2020, 19 (08) : 689 - 698
  • [39] Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions
    Maezawa, Izumi
    Swanberg, Susan
    Harvey, Danielle
    LaSalle, Janine M.
    Jin, Lee-Way
    JOURNAL OF NEUROSCIENCE, 2009, 29 (16) : 5051 - 5061
  • [40] An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders
    Baker, Steven Andrew
    Chen, Lin
    Wilkins, Angela Dawn
    Yu, Peng
    Lichtarge, Olivier
    Zoghbi, Huda Yahya
    CELL, 2013, 152 (05) : 984 - 996