PHYSIOLOGICAL AND PATHOLOGICAL CONSEQUENCES OF IDENTIFICATION OF VERY SMALL EMBRYONIC LIKE (VSEL) STEM CELLS IN ADULT BONE MARROW

被引：0
作者：
Kucia, M. [1 ]
Zuba-Surma, E. [1 ]
Wysoczynski, M. [1 ]
Dobrowolska, H. [1 ]
Reca, R. [1 ]
Ratajczak, J. [1 ]
Ratajczak, M. Z. [1 ,2 ]
机构：
[1] Univ Louisville, Stem Cell Biol Program, James Graham Brown Canc Ctr, Louisville, KY 40202 USA
[2] Pomeranian Med Univ, Dept Physiol, Szczecin, Poland
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2006年 / 57卷
关键词：
CXCR4; SDF-1; VSEL; organogenesis; regeneration; cancer metastasis;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Bone marrow (BM) contains a population of self-renewing hematopoietic stem cells (HSC) that give rise to cells from all hemato-lymphopoietic lineages. The concept that HSC could also be plastic and be able to transdifferentiate into stem/progenitor cells for different non-hematopoietic tissues became one of the most controversial issues of modern stem cell biology. Accumulating experimental evidence suggests that contribution of BM-derived stem cells to organ/tissue regeneration could be explained not by plasticity (transdifferentiation) of HSC but rather by the presence of non-hematopoietic stem cells in BM. In this review new evidence will be presented, that adult BM contains a small population of pluripotent very small embryonic-like (VSEL) stem cells. These cells are deposited in BM early during ontogenesis and could be mobilized from BM and circulate in peripheral blood during tissue/organ injury in an attempt to regenerate damaged organs. However, if these cells are mobilized at the wrong time and migrate to the wrong place they may contribute to the development of several pathologies, including tumor formation.
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页码：5 / 18
页数：14
相关论文
共 59 条
[31]   Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner [J].
Majka, M ;
Janowska-Wieczorek, A ;
Ratajczak, J ;
Ehrenman, K ;
Pietrzkowski, Z ;
Kowalska, MA ;
Gewirtz, AM ;
Emerson, SG ;
Ratajczak, MZ .
BLOOD, 2001, 97 (10) :3075-3085
[32]   Definitive hematopoiesis is autonomously initiated by the AGM region [J].
Medvinsky, A ;
Dzierzak, E .
CELL, 1996, 86 (06) :897-906
[33]   Turning blood into brain:: Cells bearing neuronal antigens generated in vivo from bone marrow [J].
Mezey, É ;
Chandross, KJ ;
Harta, G ;
Maki, RA ;
McKercher, SR .
SCIENCE, 2000, 290 (5497) :1779-1782
[34]   Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts [J].
Murry, CE ;
Soonpaa, MH ;
Reinecke, H ;
Nakajima, H ;
Nakajima, HO ;
Rubart, M ;
Pasumarthi, KBS ;
Virag, JI ;
Bartelmez, SH ;
Poppa, V ;
Bradford, G ;
Dowell, JD ;
Williams, DA ;
Field, LJ .
NATURE, 2004, 428 (6983) :664-668
[35]   Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation [J].
Nygren, JM ;
Jovinge, S ;
Breitbach, M ;
Säwén, P ;
Röll, W ;
Hescheler, J ;
Taneera, J ;
Fleischmann, BK ;
Jacobsen, SEW .
NATURE MEDICINE, 2004, 10 (05) :494-501
[36]   Hematopoiesis and stem cells:: plasticity versus developmental heterogeneity [J].
Orkin, SH ;
Zon, LI .
NATURE IMMUNOLOGY, 2002, 3 (04) :323-328
[37]   Bone marrow cells regenerate infarcted myocardium [J].
Orlic, D ;
Kajstura, J ;
Chimenti, S ;
Jakoniuk, I ;
Anderson, SM ;
Li, BS ;
Pickel, J ;
McKay, R ;
Nadal-Ginard, B ;
Bodine, DM ;
Leri, A ;
Anversa, P .
NATURE, 2001, 410 (6829) :701-705
[38]   Human hematopoietic stem/progenitor-enriched CD34+ cells are mobilized into peripheral blood during stress related to ischemic stroke or acute myocardial infarction [J].
Paczkowska, E ;
Larysz, B ;
Rzeuski, R ;
Karbicka, A ;
Jalowinski, R ;
Kornacewicz-Jach, Z ;
Ratajczak, MZ ;
Machalinski, B .
EUROPEAN JOURNAL OF HAEMATOLOGY, 2005, 75 (06) :461-467
[39]   Bone marrow as a potential source of hepatic oval cells [J].
Petersen, BE ;
Bowen, WC ;
Patrene, KD ;
Mars, WM ;
Sullivan, AK ;
Murase, N ;
Boggs, SS ;
Greenberger, JS ;
Goff, JP .
SCIENCE, 1999, 284 (5417) :1168-1170
[40]   Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function [J].
Ponomaryov, T ;
Peled, A ;
Petit, I ;
Taichman, RS ;
Habler, L ;
Sandbank, J ;
Arenzana-Seisdedos, F ;
Magerus, A ;
Caruz, A ;
Fujii, N ;
Nagler, A ;
Lahav, M ;
Szyper-Kravitz, M ;
Zipori, D ;
Lapidot, T .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (11) :1331-1339
123456