PHYSIOLOGICAL AND PATHOLOGICAL CONSEQUENCES OF IDENTIFICATION OF VERY SMALL EMBRYONIC LIKE (VSEL) STEM CELLS IN ADULT BONE MARROW

被引：0

作者：

Kucia, M. ^{[1
]}

Zuba-Surma, E. ^{[1
]}

Wysoczynski, M. ^{[1
]}

Dobrowolska, H. ^{[1
]}

Reca, R. ^{[1
]}

Ratajczak, J. ^{[1
]}

Ratajczak, M. Z. ^{[1
,2
]}

机构：

[1] Univ Louisville, Stem Cell Biol Program, James Graham Brown Canc Ctr, Louisville, KY 40202 USA

[2] Pomeranian Med Univ, Dept Physiol, Szczecin, Poland

来源：

JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2006年 / 57卷

关键词：

CXCR4; SDF-1; VSEL; organogenesis; regeneration; cancer metastasis;

D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Bone marrow (BM) contains a population of self-renewing hematopoietic stem cells (HSC) that give rise to cells from all hemato-lymphopoietic lineages. The concept that HSC could also be plastic and be able to transdifferentiate into stem/progenitor cells for different non-hematopoietic tissues became one of the most controversial issues of modern stem cell biology. Accumulating experimental evidence suggests that contribution of BM-derived stem cells to organ/tissue regeneration could be explained not by plasticity (transdifferentiation) of HSC but rather by the presence of non-hematopoietic stem cells in BM. In this review new evidence will be presented, that adult BM contains a small population of pluripotent very small embryonic-like (VSEL) stem cells. These cells are deposited in BM early during ontogenesis and could be mobilized from BM and circulate in peripheral blood during tissue/organ injury in an attempt to regenerate damaged organs. However, if these cells are mobilized at the wrong time and migrate to the wrong place they may contribute to the development of several pathologies, including tumor formation.

引用

页码：5 / 18

页数：14

共 59 条

[1] Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes [J].

Alvarez-Dolado, M ;

Pardal, R ;

Garcia-Vardugo, JM ;

Fike, JR ;

Lee, HO ;

Pfeffer, K ;

Lois, C ;

Morrison, SJ ;

Alvarez-Buylla, A .

NATURE, 2003, 425 (6961) :968-973

[2] Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1) [J].

Ara, T ;

Nakamura, Y ;

Egawa, T ;

Sugiyama, T ;

Abe, K ;

Kishimoto, T ;

Matsui, Y ;

Nagasawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :5319-5323

[3] Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium [J].

Balsam, LB ;

Wagers, AJ ;

Christensen, JL ;

Kofidis, T ;

Weissman, IL ;

Robbins, RC .

NATURE, 2004, 428 (6983) :668-673

[4]

Budasz-Rwiderska M, 2005, J Physiol Pharmacol, V56 Suppl 3, P195

[5] Integrative molecular and developmental biology of adult stem cells [J].

Bunting, KD ;

Hawley, RG .

BIOLOGY OF THE CELL, 2003, 95 (09) :563-578

[6] Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners [J].

Camargo, FD ;

Finegold, M ;

Goodell, MA .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (09) :1266-1270

[7] Failure of bone marrow cells to transdifferentiate into neural cells in vivo [J].

Castro, RF ;

Jackson, KA ;

Goodell, MA ;

Robertson, CS ;

Liu, H ;

Shine, HD .

SCIENCE, 2002, 297 (5585) :1299-1299

[8] Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 [J].

Ceradini, DJ ;

Kulkarni, AR ;

Callaghan, MJ ;

Tepper, OM ;

Bastidas, N ;

Kleinman, ME ;

Capla, JM ;

Galiano, RD ;

Levine, JP ;

Gurtner, GC .

NATURE MEDICINE, 2004, 10 (08) :858-864

[9] The hemangioblast: Cradle to clinic [J].

Cogle, CR ;

Scott, EW .

EXPERIMENTAL HEMATOLOGY, 2004, 32 (10) :885-890

[10] Somatic stem cell research for neural repair: current evidence and emerging perspectives [J].

Corti, S ;

Locatelli, F ;

Papadimitriou, D ;

Strazzer, S ;

Comi, CP .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2004, 8 (03) :329-337

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