Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke

被引：367

作者：

Holmes, Michael V. ^{[1
,2
,3
,4
]}

Millwood, Iona Y. ^{[1
,2
,3
]}

Kartsonaki, Christiana ^{[1
,2
,3
]}

Hill, Michael R. ^{[1
,2
]}

Bennett, Derrick A. ^{[1
,2
]}

Boxall, Ruth ^{[1
,2
,3
]}

Guo, Yu ^{[5
]}

Xu, Xin ^{[6
]}

Bian, Zheng ^{[5
]}

Hu, Ruying ^{[7
]}

Walters, Robin G. ^{[1
,2
]}

Chen, Junshi ^{[8
]}

Ala-Korpela, Mika ^{[9
,10
,11
,12
,13
,14
,15
]}

Parish, Sarah ^{[1
,2
,3
]}

Clarke, Robert J. ^{[1
,2
]}

Peto, Richard ^{[1
,2
]}

Collins, Rory ^{[1
,2
]}

Li, Liming ^{[5
,16
]}

Chen, Zhengming ^{[1
,2
]}

机构：

[1] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Big Data Inst Bldg,Old Rd Campus, Oxford OX3 7LF, England

[2] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England

[3] Univ Oxford, MRC, Nuffield Dept Populat Hlth, PHRU, Oxford, England

[4] Oxford Univ Hosp, Oxford Biomed Res Ctr, Natl Inst Hlth Res, Oxford, England

[5] Chinese Acad Med Sci, Beijing, Peoples R China

[6] Liuyang CDC, Changsha, Hunan, Peoples R China

[7] Zhejiang CDC, NCDs Prevent & Control Dept, Hangzhou, Zhejiang, Peoples R China

[8] Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China

[9] Univ Oulu, Fac Med, Computat Med, Oulu, Finland

[10] Bioctr Oulu, Oulu, Finland

[11] Univ Bristol, MRC, Integrat Epidemiol Unit, Bristol, Avon, England

[12] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England

[13] Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio, Finland

[14] Baker Heart & Diabet Inst, Syst Epidemiol, Melbourne, Vic, Australia

[15] Monash Univ, Alfred Hosp, Fac Med Nursing & Hlth Sci, Dept Epidemiol & Prevent Med,Sch Publ Hlth & Prev, Melbourne, Vic, Australia

[16] Peking Univ, Sch Publ Hlth, Dept Global Hlth, Beijing, Peoples R China

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2018年 / 71卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会; 中国国家自然科学基金;

关键词：

epidemiology; etiology; intracerebral hemorrhage; ischemic stroke; metabolomics; myocardial infarction; MAGNETIC-RESONANCE METABOLOMICS; ACUTE-PHASE GLYCOPROTEINS; CORONARY-ARTERY-DISEASE; RANDOMIZED-TRIALS; VASCULAR-DISEASE; LDL CHOLESTEROL; HEART-DISEASE; GENOME-WIDE; METAANALYSIS; GLYCA;

D O I：

10.1016/j.jacc.2017.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke subtypes. OBJECTIVES This study sought to investigate the associations of plasma metabolic markers with risks of incident MI, ischemic stroke (IS), and intracerebral hemorrhage (ICH). METHODS hi a nested case-control study (912 MI, 1,146 IS, and 1138 ICH cases, and 1,466 common control subjects) 30 to 79 years of age in China Kadoorie Biobank, nuclear magnetic resonance spectroscopy measured 225 metabolic markers in baseline plasma samples. Logistic regression was used to estimate adjusted odds ratios (ORs) fora 1-SD higher metabolic marker. RESULTS Very low-, intermediate-, and low-density lipoprotein particles were positively associated with MI and IS. High-density lipoprotein (HDL) particles were inversely associated with MI apart from small HDL. In contrast, no lipoprotein particles were associated with ICH. Cholesterol in large HDL was inversely associated with MI and IS (OR: 0.79 and 0.88, respectively), whereas cholesterol in small HDL was not (OR: 0.99 and 1.06, respectively). Triglycerides within all lipoproteins, including most HDL particles, were positively associated with MI, with a similar pattern for IS. Glycoprotein acetyts, ketone bodies, glucose, and docosahexaenoic add were associated with all 3 diseases. The 225 metabolic markers showed concordant associations between MI and IS, but not with ICH. CONCLUSIONS Lipoproteins and lipids showed similar associations with MI and IS, but not with ICH. Within HDL particles, cholesterol concentrations were inversely associated, whereas triglyceride concentrations were positively associated with ML Glycoprotein acetyls and several non-lipid-related metabolites associated with all 3 diseases. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：620 / 632

页数：13

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