Low-level exposure to ambient particulate matter is associated with systemic inflammation in ischemic heart disease patients

被引:101
作者
Huttunen, Kati [1 ,2 ]
Siponen, Taina [2 ]
Salonen, Iiris [3 ]
Yli-Tuomi, Tarja [2 ]
Aurela, Minna [5 ]
Dufva, Hilkka [4 ]
Hillamo, Risto [5 ]
Linkola, Eeva [6 ]
Pekkanen, Juha [2 ,7 ]
Pennanen, Arto [2 ]
Peters, Annette [8 ]
Salonen, Raimo O. [2 ]
Schneider, Alexandra [8 ]
Tiittanen, Pekka [2 ]
Hirvonen, Maija-Riitta [1 ,2 ]
Lanki, Timo [2 ]
机构
[1] Univ Eastern Finland, Dept Environm Sci, Kuopio 70211, Finland
[2] Natl Inst Hlth & Welf, Dept Environm Hlth, Kuopio 70701, Finland
[3] Carea, Kymenlaalcso Hosp Serv, Kotka 48210, Finland
[4] Kymenlaakso Univ Appl Sci, Kotka 48401, Finland
[5] Finnish Meteorol Inst, FIN-00101 Helsinki, Finland
[6] City Kotka Environm Ctr, Kotka 48200, Finland
[7] Univ Eastern Finland, Kuopio 70211, Finland
[8] Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherberg, Germany
基金
芬兰科学院;
关键词
Air pollution; Inflammation; Ischemic heart disease; Personal exposure; Wildfires; AIR-POLLUTION; ULTRAFINE PARTICLES; RATE-VARIABILITY; BLOOD MARKERS; IN-VITRO; FINE; RISK; COARSE; PM2.5; BIOMARKERS;
D O I
10.1016/j.envres.2012.04.004
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Short-term exposure to ambient air pollution is associated with increased cardiovascular mortality and morbidity. This adverse health effect is suggested to be mediated by inflammatory processes. The purpose of this study was to determine if low levels of particulate matter, typical for smaller cities, are associated with acute systemic inflammation. Fifty-two elderly individuals with ischemic heart disease were followed for six months with biweekly clinical visits in the city of Kotka, Finland. Blood samples were collected for the determination of inflammatory markers interleukin (IL)-1 beta, IL-6, IL-8, IL-12, interferon (IFN)gamma, C-reactive protein (CRP), fibrinogen, myeloperoxidase and white blood cell count. Particle number concentration and fine particle (particles with aerodynamic diameters <2.5 mu m (PM2.5)) as well as thoracic particle (particles with aerodynamic diameters <10 mu m (PM10)) mass concentration were measured daily at a fixed outdoor measurement site. Light-absorbance of PM2.5 filter samples, an indicator of combustion derived particles, was measured with a smoke-stain reflectometer. In addition, personal exposure to PM2.5 was measured with portable photometers. During the study period, wildfires in Eastern Europe led to a 12-day air pollution episode, which was excluded from the main analyses. Average ambient PM2.5 concentration was 8.7 mu g/m(3). Of the studied pollutants, PM2.5 and absorbance were most strongly associated with increased levels of inflammatory markers: most notably with C-reactive protein and IL-12 within a few days of exposure. There was also some evidence of an effect of particulate air pollution on fibrinogen and myeloperoxidase. The concentration of IL-12 was considerably (227%) higher during than before the forest fire episode. These findings show that even low levels of particulate air pollution from urban sources are associated with acute systemic inflammation. Also particles from wildfires may exhibit pro-inflammatory effects. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:44 / 51
页数:8
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