DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet

被引:51
作者
Chen, Jingnan [1 ,2 ]
Jiang, Yue [1 ,2 ]
Liang, Yintong [3 ]
Tian, Xiaoyu [4 ,5 ]
Peng, Cheng [3 ]
Ma, Ka Ying [3 ]
Liu, Jian [4 ,5 ]
Huang, Yu [4 ,5 ]
Chen, Zhen-Yu [3 ]
机构
[1] Hong Kong Baptist Univ, Dept Biol, Kowloon Tong, Hong Kong, Peoples R China
[2] Hong Kong Baptist Univ, Kwong Living Trust Food Safety & Anal Lab, Kowloon Tong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Sch Life Sci, Food & Nutr Sci Programme, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China
关键词
Docosahexaenoic acid; Docosapentaenoic acid; Total cholesterol; HMG-CoA reductase; SREBP-2; Vascular reactivity; DECREASES PLASMA-CHOLESTEROL; HEPATIC LDL RECEPTOR; DOCOSAHEXAENOIC ACID; DOWN-REGULATION; UP-REGULATION; INTESTINAL NPC1L1; OXIDATIVE STRESS; CYCLOOXYGENASE-2; EXPRESSION; PROTEIN;
D O I
10.1016/j.atherosclerosis.2012.01.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present study examined the cholesterol-lowering activity of omega-3 docosapentaenoic acid (DPA n-3), omega-6 docosapentaenoic acid (DPA n-6) and docosahexaenoic acid (DHA), and their interaction with gene expression of transporters, receptors and enzymes involved in cholesterol absorption and metabolism as well as their effect on aortic function. Forty hamsters were fed either the control diet containing 0.4% stearic acid or one of the three experimental diets containing 0.4% DPA n-3, 0.4% DPA n-6 and 0.4% DHA. Results showed that supplementation of these three fatty acids reduced plasma total cholesterol (TC) and non high-density-lipoprotein cholesterol (non-HDL-C) by 29-33% and 29-50%, respectively, compared with the control. The reduction in TC and non-HDL-C was accompanied by down-regulation of hepatic SREBP-2 and HMG-CoA reductase. Aorta from DPA n-3 and DHA groups was found to have significantly lesser tension and relax better than that from the control and DPA n-6 hamsters, largely mediated by their inhibition on the gene expression of cycloxygense-2 (COX-2). It was concluded that all three fatty acids were beneficial in improving lipoprotein profile with DPA n-3 and DHA having better effect on aortic function. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:397 / 404
页数:8
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