Synthesis, characterization and biological studies of a novel Cu(II) Schiff base complex

被引：31

作者：

Thirunavukkarasu, Thangavel ^{[1
]}

Sparkes, Hazel A. ^{[2
]}

Natarajan, Karuppannan ^{[3
]}

Gnanasoundari, V. G. ^{[1
]}

机构：

[1] CBM Coll, Dept Chem, Coimbatore 641042, Tamil Nadu, India

[2] Univ Bristol, Dept Chem, Bristol BS8 1TS, Avon, England

[3] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India

来源：

INORGANICA CHIMICA ACTA | 2018年 / 473卷

关键词：

Schiff base ligand; Copper(II) complex; DNA/protein binding; Cytotoxicity; BOVINE SERUM-ALBUMIN; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE; DNA-BINDING; CYTOTOXIC ACTIVITY; NUCLEASE ACTIVITY; METAL-COMPLEXES; PHARMACOLOGICAL EVALUATION; COORDINATION CHEMISTRY; HYDRAZONE COMPLEXES;

D O I：

10.1016/j.ica.2018.01.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A Cu(II) complex was obtained from the reaction of 4-(diethylamino)-3-quinolin-3-ylimino-methyl-2-phenol with [CuCl2(PPh3)2]. The ligand coordinated to the metal ion in a monobasic bidentate fashion. The molecular structure of the complex has been confirmed by single crystal X-ray diffraction. Both the ligand and complex were characterized by various spectroscopic techniques. Using the UV-visible and fluorescence spectroscopic studies, the binding interactions of the compounds with CT-DNA and bovine serum albumin protein were evaluated. The results indicated that the compounds are efficient DNA/protein binders. The cytotoxicity of the ligand and complex against A549 (lung cancer) and MCF7 (breast cancer) cell lines was also investigated in vitro conditions using the MTT assay method which showed significant anticancer activity. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：255 / 262

页数：8

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