Stability Analysis of Cefaclor and Its Inclusion Complexes of β-Cyclodextrin by Thin-Layer Chromatography and Densitometry

被引：5

作者：

Dabrowska, Monika ^{[1
]}

Krzek, Jan ^{[1
]}

Miekina, Ewa ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Inorgan & Analyt Chem, PL-30688 Krakow, Poland

来源：

JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2012年 / 25卷 / 02期

关键词：

Thin-layer chromatography; Densitometric detection; Cefaclor; Inclusion complexes of beta-cyclodextrin; CAPILLARY-ZONE-ELECTROPHORESIS; MAJOR DEGRADATION PRODUCTS; CEPHALOSPORIN ANTIBIOTICS; PHARMACEUTICAL-PREPARATIONS; LIQUID-CHROMATOGRAPHY; SPECTROPHOTOMETRIC DETERMINATION; QUANTITATIVE-ANALYSIS; STRUCTURE ELUCIDATION; MASS-SPECTROMETRY; HUMAN PLASMA;

D O I：

10.1556/JPC.25.2012.2.7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The stability of cefaclor and its inclusion complex of beta-cyclodextrin was investigated, including an effect of pH solution, temperature, and incubation time. Favorable retention parameters (R-F, R-S, alpha) were obtained under developed conditions, which guarantee good separation of studied components. The degradation processes were described with kinetic and thermodynamic parameters (k, t(0.1), t(0.5), and E-u). The identification of degradation products was performed with the application of proton nuclear magnetic resonance spectrometry and thin-layer chromatography with densitometry.

引用

页码：127 / 132

页数：6

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