Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

被引：25
作者：
Downar, Jonathan [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada
[2] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada
[3] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada
[4] Univ Hlth Network, Ctr Mental Hlth, Toronto, ON, Canada
[5] Univ Hlth Network, Poul Hansen Ctr Depress, MRI Guided rTMS Clin, Toronto, ON, Canada
来源：
CURRENT BIOLOGY | 2019年 / 29卷 / 02期
关键词：
MAJOR DEPRESSION; PREFRONTAL CORTEX; CONNECTIVITY; TOLERABILITY; STIMULATION; SAFETY; RTMS; HZ;
D O I：
10.1016/j.cub.2018.11.057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies.
引用
收藏
页码：R59 / R62
页数：5
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