Orbitofrontal Cortex: A 'Non-rewarding' New Treatment Target in Depression?

被引：25

作者：

Downar, Jonathan ^{[1
,2
,3
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]}

机构：

[1] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada

[2] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada

[3] Univ Hlth Network, Krembil Res Inst, Toronto, ON, Canada

[4] Univ Hlth Network, Ctr Mental Hlth, Toronto, ON, Canada

[5] Univ Hlth Network, Poul Hansen Ctr Depress, MRI Guided rTMS Clin, Toronto, ON, Canada

来源：

CURRENT BIOLOGY | 2019年 / 29卷 / 02期

关键词：

MAJOR DEPRESSION; PREFRONTAL CORTEX; CONNECTIVITY; TOLERABILITY; STIMULATION; SAFETY; RTMS; HZ;

D O I：

10.1016/j.cub.2018.11.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Self-perpetuating activity in lateral orbitofrontal regions has been theorized to sustain the negative thoughts and emotions of depression. A new study demonstrates that disrupting such activity may yield rapid improvements in mood state, pointing the way to novel treatment strategies.

引用

收藏

页码：R59 / R62

页数：5

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