Error-prone DNA polymerases: Novel structures and the benefits of infidelity

被引：103

作者：

Friedberg, EC ^{[1
]}

Fischhaber, PL

Kisker, C

机构：

[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA

[2] SUNY Stony Brook, Dept Pharmacol Sci, Ctr Struct Biol, Stony Brook, NY 11794 USA

来源：

CELL | 2001年 / 107卷 / 01期

关键词：

D O I：

10.1016/S0092-8674(01)00509-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.

引用

页码：9 / 12

页数：4

共 17 条

[1] 5′-Deoxyribose phosphate lyase activity of human DNA polymerase ι in vitro [J].

Bebenek, K ;

Tissier, A ;

Frank, EG ;

McDonald, JP ;

Prasad, R ;

Wilson, SH ;

Woodgate, R ;

Kunkel, TA .

SCIENCE, 2001, 291 (5511) :2156-2159

[2]

FRIEDBERG EC, 1995, DNA REPAIR MUTAGENES

[3] Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase λ -: A possible role in base excision repair [J].

García-Díaz, M ;

Bebenek, K ;

Kunkel, TA ;

Blanco, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :34659-34663

[4] Human DNA polymerase κ:: A novel DNA polymerase of unknown biological function encoded by the DINB1 gene [J].

Gerlach, VL ;

Feaver, WJ ;

Fischhaber, PL ;

Richardson, JA ;

Aravind, L ;

Koonin, EV ;

Bebenek, K ;

Kunkel, TA ;

Friedberg, EC .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2000, 65 :41-49

[5] Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η [J].

Haracska, L ;

Yu, SL ;

Johnson, RE ;

Prakash, L ;

Prakash, S .

NATURE GENETICS, 2000, 25 (04) :458-461

[6] Role of DNA polymerase η in the bypass of a (6-4) TT photoproduct [J].

Johnson, RE ;

Haracska, L ;

Prakash, S ;

Prakash, L .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (10) :3558-3563

[7] DNA replication fidelity [J].

Kunkel, TA ;

Bebenek, R .

ANNUAL REVIEW OF BIOCHEMISTRY, 2000, 69 :497-529

[8] Crystal structure of a Y-family DNA polymerase in action: A mechanism for error-prone and lesion-bypass replication [J].

Ling, H ;

Boudsocq, F ;

Woodgate, R ;

Yang, W .

CELL, 2001, 107 (01) :91-102

[9] Xeroderma pigmentosum variant: From a human genetic disorder to a novel DNA polymerase [J].

Masutani, C ;

Kusumoto, R ;

Yamada, A ;

Yuasa, M ;

Araki, M ;

Nogimori, T ;

Yokoi, M ;

Eki, T ;

Iwai, S ;

Hanaoka, F .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2000, 65 :71-80

[10] Low fidelity DNA synthesis by human DNA polymerase-η [J].

Matsuda, T ;

Bebenek, K ;

Masutani, C ;

Hanaoka, F ;

Kunkel, TA .

NATURE, 2000, 404 (6781) :1011-1013

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