Core Scaffold-Inspired Concise Synthesis of Chiral Spirooxindole-Pyranopyrimidines with Broad-Spectrum Anticancer Potency

被引：107

作者：

Jiang, Xianxing ^{[1
]}

Sun, Yulong ^{[1
]}

Yao, Jia ^{[1
]}

Cao, Yiming ^{[1
]}

Kai, Ming ^{[1
]}

He, Ning ^{[1
]}

Zhang, Xiaoyuan ^{[1
]}

Wang, Yiqing ^{[1
]}

Wang, Rui ^{[1
]}

机构：

[1] Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Inst Biochem & Mol Biol, Cent Lab,Hosp 1, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 05期

基金：

中国国家自然科学基金;

关键词：

anticancer activity; asymmetric synthesis; pyranopyrimidines; spiroheterocycles; DOUBLY STEREOCONTROLLED APPROACH; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC CATALYSIS; MANNICH REACTION; OXINDOLES; CONSTRUCTION; DISCOVERY; EFFICIENT; THIOUREAS; AMINE;

D O I：

10.1002/adsc.201100792

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Due to the lack of tumor-specific anticancer agents, the discovery and development of new types of highly selective anticancer agents is still a very urgent topic. Herein, we present our contribution to concise construction of novel chiral spirooxindole-type pyranopyrimidines exhibiting a unique profile of biological activities. We have found that this new type of spiro alkaloid could inhibit the proliferation of various cancer cells in a preliminary biological evaluation. These findings suggested that spirooxindole-type pyranopyrimidines, developed by an asymmetric Michael/cyclization strategy, can potentially serve as a new kind of anticancer candidate.

引用

页码：917 / 925

页数：9

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