Molecular Profiling of Follicular Variant of Papillary Thyroid Cancer

被引：2
|
作者：
Spirina, L., V [1 ,2 ]
Chizhevskaya, S. Yu [1 ]
Kondakova, I., V [1 ]
机构：
[1] Tomsk Natl Res Med Ctr, Canc Res Inst, Tomsk, Russia
[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 01期
关键词：
follicular variant of papillary thyroid cancer; transcriptional factors; growth factors; AKT; m-TOR signaling path; BRAF;
D O I：
10.1007/s10517-020-04830-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The molecular features of the follicular variant of papillary thyroid cancer are closely related to the clinical behavior of the tumor and the prognosis of the disease. BRAF-V600E mutations in patients with a follicular variant of papillary thyroid cancer have not been identified; however, the majority of patients had T3-4N0M0 stage of the disease. Changes in the expression of transcription and growth factors and AKT/m-TOR signaling pathway components were detected. In addition, hyperexpression of m-TOR and 4EBP1 kinases and CAIX enzyme was shown compared to the classical variant of papillary thyroid cancer, where an increase in the nuclear factor NF-kappa B p65 and c-RAF kinase expression was observed.
引用
收藏
页码：85 / 88
页数：4
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