Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease

被引：18

作者：

Sepulveda, Denisse ^{[1
,2
,3
]}

Cisternas-Olmedo, Marisol ^{[1
,2
,3
]}

Arcos, Javiera ^{[1
,2
,3
]}

Nassif, Melissa ^{[1
,4
]}

Vidal, Rene L. ^{[1
,2
,3
]}

机构：

[1] Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile

[2] Univ Chile, Biomed Neurosci Inst, Santiago, Chile

[3] Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

[4] Univ Mayor, Fac Ciencias, Escuela Biotecnol, Santiago, Chile

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷

关键词：

autophagy-lysosomal pathway; alpha-syn exosomal secretion; Parkinson's disease progression; biomarker; degradation; LIPID RAFTS; PROTEASOME DYSFUNCTION; DEPENDENT ENDOCYTOSIS; MEDIATED ENDOCYTOSIS; CAVEOLIN-1; INTERACTS; NATURAL-PRODUCTS; LEWY BODIES; CELL-DEATH; COMPLEX-I; MUTATIONS;

D O I：

10.3389/fnmol.2022.805087

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (alpha-syn) protein aggregates. It has been reported that the levels of exosomal alpha-syn of neuronal origin in plasma correlate significantly with motor dysfunction, highlighting the exosomes containing alpha-syn as a potential biomarker of PD. In addition, it has been found that the selective autophagy-lysosomal pathway (ALP) contributes to the secretion of misfolded proteins involved in neurodegenerative diseases. In this review, we describe the evidence that supports the relationship between the ALP and alpha-syn exosomal secretion on the PD progression and its implications in the diagnosis and progression of this pathology.

引用

页数：15

共 202 条

[11] Animal models of Parkinson's disease [J].

Betarbet, R ;

Sherer, TB ;

Greenamyre, JT .

BIOESSAYS, 2002, 24 (04) :308-318

[12] Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Gαq-coupled protein receptors [J].

Bhatnagar, A ;

Sheffler, DJ ;

Kroeze, WK ;

Compton-Toth, B ;

Roth, BL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (33) :34614-34623

[13] LRRK2 modifies α-syn pathology and spread in mouse models and human neurons [J].

Bieri, Gregor ;

Brahic, Michel ;

Bousset, Luc ;

Couthouis, Julien ;

Kramer, Nicholas J. ;

Ma, Rosanna ;

Nakayama, Lisa ;

Monbureau, Marie ;

Defensor, Erwin ;

Schuele, Birgitt ;

Shamloo, Mehrdad ;

Melki, Ronald ;

Gitler, Aaron D. .

ACTA NEUROPATHOLOGICA, 2019, 137 (06) :961-980

[14] Internalization, axonal transport and release of fibrillar forms of alpha-synuclein [J].

Bieri, Gregor ;

Gitler, Aaron D. ;

Brahic, Michel .

NEUROBIOLOGY OF DISEASE, 2018, 109 :219-225

[15] Caveolin interacts with Trk A and p75NTR and regulates neurotrophin signaling pathways [J].

Bilderback, TR ;

Gazula, VR ;

Lisanti, MP ;

Dobrowsky, RT .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (01) :257-263

[16] Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes [J].

Bliederhaeuser, Corinna ;

Grozdanov, Veselin ;

Speidel, Anna ;

Zondler, Lisa ;

Ruf, Wolfgang P. ;

Bayer, Hanna ;

Kiechle, Martin ;

Feiler, Marisa S. ;

Freischmidt, Axel ;

Brenner, David ;

Witting, Anke ;

Hengerer, Bastian ;

Faendrich, Marcus ;

Ludolph, Albert C. ;

Weishaupt, Jochen H. ;

Gillardon, Frank ;

Danzer, Karin M. .

ACTA NEUROPATHOLOGICA, 2016, 131 (03) :379-391

[17] LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease [J].

Bonello, Fiona ;

Hassoun, Sidi-Mohamed ;

Mouton-Liger, Francois ;

Shin, Yea Seul ;

Muscat, Adeline ;

Tesson, Christelle ;

Lesage, Suzanne ;

Beart, Philip M. ;

Brice, Alexis ;

Krupp, Johannes ;

Corvol, Jean-Christophe ;

Corti, Olga .

HUMAN MOLECULAR GENETICS, 2019, 28 (10) :1645-1660

[18] Caveolin proteins are essential for distinct effects of membrane estrogen receptors in neurons [J].

Boulware, Marissa I. ;

Kordasiewicz, Holly ;

Mermelstein, Paul G. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (37) :9941-9950

[19] Synucleinopathies: Where we are and where we need to go [J].

Bras, Ines Caldeira ;

Dominguez-Meijide, Antonio ;

Gerhardt, Ellen ;

Koss, David ;

Lazaro, Diana F. ;

Santos, Patricia, I ;

Vasili, Eftychia ;

Xylaki, Mary ;

Outeiro, Tiago Fleming .

JOURNAL OF NEUROCHEMISTRY, 2020, 153 (04) :433-454

[20] Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies [J].

Brockmann, Kathrin ;

Quadalti, Corinne ;

Lerche, Stefanie ;

Rossi, Marcello ;

Wurster, Isabel ;

Baiardi, Simone ;

Roeben, Benjamin ;

Mammana, Angela ;

Zimmermann, Milan ;

Hauser, Ann-Kathrin ;

Deuschle, Christian ;

Schulte, Claudia ;

Waniek, Katharina ;

Lachmann, Ingolf ;

Sjodin, Simon ;

Brinkmalm, Ann ;

Blennow, Kaj ;

Zetterberg, Henrik ;

Gasser, Thomas ;

Parchi, Piero .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2021, 9 (01)

← 1 2 3 4 5 6 7 8 9 10 →