Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease

被引：18

作者：

Sepulveda, Denisse ^{[1
,2
,3
]}

Cisternas-Olmedo, Marisol ^{[1
,2
,3
]}

Arcos, Javiera ^{[1
,2
,3
]}

Nassif, Melissa ^{[1
,4
]}

Vidal, Rene L. ^{[1
,2
,3
]}

机构：

[1] Univ Mayor, Fac Ciencias, Ctr Integrat Biol, Santiago, Chile

[2] Univ Chile, Biomed Neurosci Inst, Santiago, Chile

[3] Gerosci Ctr Brain Hlth & Metab, Santiago, Chile

[4] Univ Mayor, Fac Ciencias, Escuela Biotecnol, Santiago, Chile

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷

关键词：

autophagy-lysosomal pathway; alpha-syn exosomal secretion; Parkinson's disease progression; biomarker; degradation; LIPID RAFTS; PROTEASOME DYSFUNCTION; DEPENDENT ENDOCYTOSIS; MEDIATED ENDOCYTOSIS; CAVEOLIN-1; INTERACTS; NATURAL-PRODUCTS; LEWY BODIES; CELL-DEATH; COMPLEX-I; MUTATIONS;

D O I：

10.3389/fnmol.2022.805087

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (alpha-syn) protein aggregates. It has been reported that the levels of exosomal alpha-syn of neuronal origin in plasma correlate significantly with motor dysfunction, highlighting the exosomes containing alpha-syn as a potential biomarker of PD. In addition, it has been found that the selective autophagy-lysosomal pathway (ALP) contributes to the secretion of misfolded proteins involved in neurodegenerative diseases. In this review, we describe the evidence that supports the relationship between the ALP and alpha-syn exosomal secretion on the PD progression and its implications in the diagnosis and progression of this pathology.

引用

页数：15

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