Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis

被引：38

作者：

Wang, Leiming ^{[1
]}

Yang, Xi ^{[1
]}

Zhou, Fei ^{[1
]}

Sun, Xuesi ^{[1
]}

Li, Shulin ^{[1
]}

机构：

[1] Xuzhou Med Univ, Affiliated Shuyang Hosp, Dept Gen Surg, 9 Yingbin Rd, Suqian City 223600, Jiangsu, Peoples R China

来源：

BIOENGINEERED | 2022年 / 13卷 / 03期

关键词：

CircUBAP2; cisplatin; TNBC; ceRNA; PI3K; AKT; mTOR signaling; SQUAMOUS-CELL CARCINOMA; ACTIVATING PI3K/AKT/MTOR; PROMOTES; METASTASIS; PROLIFERATION; PROGRESSION;

D O I：

10.1080/21655979.2022.2036894

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Circular RNAs (CircRNAs) have attracted increasing attention in the diagnosis and treatment of human cancers. CircUBAP2 has been identified to promote the progression of triple-negative breast cancer (TNBC), but the function of circUBAP2 in the cisplatin (DDP) resistance of TNBC remains obscure. Our investigation showed that circUBAP2 was significantly upregulated in DDP-resistant TNBC and TNBC sensitivity to DDP could be enhanced by silencing of circUBAP2. Moreover, circUBAP2 was revealed to be a ceRNA for miR-300 to upregulate the expression of anti-silencing function 1B histone chaperone (ASF1B). The effect of circUBAP2/miR-300/ASF1B axis on DDP resistance of TNBC was evaluated by rescue experiments, which demonstrated that circUBAP2 inhibited TNBC sensitivity to DDP through miR-300/ASF1B axis. Furthermore, it was discovered that ASF1B activated PI3K/AKT/mTOR signaling to facilitate the DDP resistance of TNBC cells. In summary, this research revealed a novel regulatory mechanism that circUBAP2 functioned as ceRNA of miR-300 to upregulate ASF1B, which further triggered the PI3K/AKT/mTOR (PAM) signaling to enhance the DDP resistance of TNBC.

引用

页码：7197 / 7208

页数：12

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