Levodopa challenge test: indications, protocol, and guide

被引：78

作者：

Saranza, Gerard ^{[1
,2
]}

Lang, Anthony E. ^{[1
,2
,3
,4
]}

机构：

[1] Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[2] Toronto Western Hosp, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[4] Toronto Western Hosp, Movement Disorders Clin, 399 Bathurst St, Toronto, ON M5T 2S8, Canada

来源：

JOURNAL OF NEUROLOGY | 2021年 / 268卷 / 09期

关键词：

Levodopa challenge test; Parkinson's disease; DBS screening; Levodopa responsiveness; Levodopa unresponsiveness; Short-duration response; LONG-DURATION RESPONSE; ADVANCED PARKINSONS-DISEASE; DEEP BRAIN-STIMULATION; CORE ASSESSMENT PROGRAM; CONSENSUS STATEMENT; DIAGNOSIS; PHARMACODYNAMICS;

D O I：

10.1007/s00415-020-09810-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A drug challenge test in Parkinson's disease, such as the levodopa challenge test (LCT), is an easy and generally safe procedure, which has been used by clinicians for various indications. The results of the test have significant implications in the management of patients, from preoperative evaluation for deep brain stimulation to providing the basis for medication adjustments to address motor or non-motor fluctuations and dyskinesias. This paper reviews the different indications and protocols commonly used in an acute LCT. Potential complications of the procedure and an overview of levodopa responsiveness and unresponsiveness are also discussed.

引用

页码：3135 / 3143

页数：9

共 55 条

[41] Subjective Perceived Motor Improvement after Acute Levodopa Challenge in Parkinson's Disease [J].

Rabel, Constance ;

Le Goff, Floriane ;

Lefaucheur, Romain ;

Ozel, Gulden ;

Fetter, Damien ;

Rouille, Audrey ;

Maltete, David .

JOURNAL OF PARKINSONS DISEASE, 2016, 6 (04) :779-785

[42] Impact of Safety Warning on Domperidone Prescribing for Geriatric Patients in South Korea: Analysis of National Insurance Claim Data [J].

Rhew, Kiyon ;

Han, Nayoung ;

Oh, Jung Mi .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2019, 16 (16)

[43] Dopaminergic Effect on Non-Motor Symptoms in Late Stage Parkinson's Disease [J].

Rosqvist, Kristina ;

Odin, Per ;

Hagell, Peter ;

Iwarsson, Susanne ;

Nilsson, Maria H. ;

Storch, Alexander .

JOURNAL OF PARKINSONS DISEASE, 2018, 8 (03) :409-420

[44]

ROSSI P, 2001, FOCUS PARKINSONS DIS, V13, P60

[45]

*ROYAL COLL PHYS, 2017, PARK DIS NAT CLIN GU

[46]

Ruonala V, 2015, IEEE ENG MED BIO, P6162, DOI 10.1109/EMBC.2015.7319799

[47]

Schade S, 2017, MOV DISORD CLIN PRAC, V4, P755, DOI 10.1002/mdc3.12511

[48] Frailty phenotype and the role of levodopa challenge test in geriatric inpatients with mild parkinsonian signs [J].

Seiffert, Piotr ;

Derejczyk, Jarosaw ;

Kawa, Jacek ;

Marcisz, Czeslaw ;

Czernek, Malgorzata ;

Szymszal, Jan ;

Kapko, Wojciech ;

Bugdol, Monika ;

Torbus, Anna ;

Stepien-Wyrobiec, Olga .

BIOGERONTOLOGY, 2017, 18 (04) :641-650

[49] Levodopa unresponsive symptoms in Parkinson disease [J].

Sethi, Kapil .

MOVEMENT DISORDERS, 2008, 23 :S521-S533

[50] Practice Parameter: Diagnosis and prognosis of new onset Parkinson disease (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology [J].

Suchowersky, O ;

Reich, S ;

Perlmutter, J ;

Zesiewicz, T ;

Gronseth, G ;

Weiner, WJ .

NEUROLOGY, 2006, 66 (07) :968-975

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