SND1 acts as a functional target of miR-330-5p involved in modulating the proliferation, apoptosis and invasion of colorectal cancer cells

被引：4

作者：

Deng, Jiaqiang ^{[1
]}

Liu, Shengpeng ^{[1
]}

Zhao, Lili ^{[1
]}

Li, Yan ^{[1
]}

Shi, Junyang ^{[1
]}

Zhang, Hua ^{[1
]}

Zhao, Yuxuan ^{[1
]}

Han, Liping ^{[1
]}

Wang, Huani ^{[1
]}

Yan, Yan ^{[1
]}

Zhao, Hong ^{[1
]}

Zou, Fangdong ^{[1
]}

机构：

[1] Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, Chengdu 610065, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 615卷

关键词：

miR-330-5p; SND1; Colorectal cancer; Proliferation; Apoptosis; Metastasis; PRIMARY TUMOR;

D O I：

10.1016/j.bbrc.2022.05.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) play a crucial role in cancer progression due to their capability to modulate the expression of various target genes. However, given the heterogeneity of tumor cells, miRNAs have been confirmed to exert different regulatory effects. Here, bioinformatic analysis results indicated that expression of miR-330-5p is decreased in colorectal cancer (CRC) tissues and inversely correlated with SND1 expression. Notably, ectopic expression of miR-330-5p restrained tumor cell proliferation, migration, and enhance the sensitivity of CRC cells to 5-FU. Moreover, similar phenotypes were substantiated after inhibition of SND1 expression using RNA interference. Conversely, overexpression of SND1 facilitated the malignant phenotypes of CRC cells and restored miR-330-5p-mediated tumor-suppressive activities in CRC cells. Mechanistically, miR-330-5p directly binds to SND1-3'-untranslated region (3'-UTR), thus involving in inhibiting CRC cells proliferation and invasion and promoting apoptosis. Taken together, miR-330-5p may act as a tumor suppressor by targeting the expression of SND1, suggesting that the miR-330-5p/SND1 axis may be a meaningful regulator for CRC intervention. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：116 / 122

页数：7

共 30 条

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