The purpose of this retrospective study was to evaluate the role of (18)F-FDG PET or PET/CT in the prediction of patient outcome in children and young adults affected by rhabdomyosarcoma. Methods: Forty-one patients with histology-proven rhabdomyosarcoma who underwent PET or PET/CT were identified (age range, 1-20 y; mean age +/- SD, 9.9 +/- 5.8 y). Tumor maximum standardized uptake value (SUV(max)) and visually rated metabolic activity, as well as the presence of metabolically active lymph nodes and distant metastases, were compared with event-free and overall survival. Multivariate Cox regression analyses were performed to compare the prediction of outcome according to metabolic tumor intensity in relation to established prognostic factors. Results: Kaplan-Meier analyses revealed a significantly shorter overall survival in primary tumors visually rated as highly metabolically active or with a ratio of SUVmax to SUV of the liver above 4.6. In addition, metabolically active lymph node and distant site involvement was indicative of significantly lower survival rates. On multivariate Cox regression analysis, the impact of intensity or SUV(max) of the primary tumor on outcome failed to attain significance, although PET performed better than some of the prognostic factors established in larger patient groups (P = 0.081). Conclusion: (18)F-FDG PET/CT is a valuable tool for initial staging in children affected by rhabdomyosarcoma. (18)F-FDG PET/CT may be an additional predictor of outcome and may be used to refine risk-adapted therapy. PET performed better than some established risk factors. The borderline significance level of primary tumor metabolism in multivariate testing may be an effect of the limited sample size. Further prospective evaluations are warranted.
机构:
Yokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Tateishi, Ukihide
;
Hosono, Ako
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Pediat Oncol, Tokyo, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Hosono, Ako
;
Makimoto, Atsushi
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Pediat Oncol, Tokyo, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Makimoto, Atsushi
;
Nakamoto, Yuki
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Kyoto, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Nakamoto, Yuki
;
Kaneta, Tomohiro
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Diagnost Radiol, Grad Sch Med, Sendai, Miyagi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Kaneta, Tomohiro
;
Fukuda, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Diagnost Radiol, Grad Sch Med, Sendai, Miyagi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Fukuda, Hiroshi
;
Murakami, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Dokkyo Med Univ, PET Ctr, Tochigi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Murakami, Koji
;
Terauchi, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Canc Screening, Res Ctr Canc Prevent & Screening, Tokyo 104, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Terauchi, Takashi
;
Suga, Tsuyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Kyoto, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Suga, Tsuyoshi
;
Inoue, Tomio
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Inoue, Tomio
;
Kim, Edmund E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Div Diagnost Imaging, Houston, TX 77030 USAYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
机构:
Yokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Tateishi, Ukihide
;
Hosono, Ako
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Pediat Oncol, Tokyo, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Hosono, Ako
;
Makimoto, Atsushi
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Pediat Oncol, Tokyo, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Makimoto, Atsushi
;
Nakamoto, Yuki
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Kyoto, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Nakamoto, Yuki
;
Kaneta, Tomohiro
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Diagnost Radiol, Grad Sch Med, Sendai, Miyagi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Kaneta, Tomohiro
;
Fukuda, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Dept Diagnost Radiol, Grad Sch Med, Sendai, Miyagi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Fukuda, Hiroshi
;
Murakami, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Dokkyo Med Univ, PET Ctr, Tochigi, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Murakami, Koji
;
Terauchi, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Canc Screening, Res Ctr Canc Prevent & Screening, Tokyo 104, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Terauchi, Takashi
;
Suga, Tsuyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Kyoto Univ, Grad Sch Med, Dept Diagnost Imaging & Nucl Med, Kyoto, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Suga, Tsuyoshi
;
Inoue, Tomio
论文数: 0引用数: 0
h-index: 0
机构:
Yokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, JapanYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan
Inoue, Tomio
;
Kim, Edmund E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Div Diagnost Imaging, Houston, TX 77030 USAYokohama City Univ, Dept Radiol, Sch Med, Kanazawa Ku, Kanagawa 2360004, Japan