Liposarcoma Multimodality Management and Future Targeted Therapies

被引：116

作者：

Crago, Aimee M. ^{[1
,2
,3
]}

Dickson, Mark A. ^{[1
,4
,5
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sarcoma Dis Management Team, 1275 York Ave, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Surg, Gastr & Mixed Tumor Serv, 1275 York Ave,H1220, New York, NY 10065 USA

[3] Weill Cornell Med Coll, Dept Surg, 1300 York Ave, New York, NY USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, Sarcoma Oncol Serv, 300 East 66th St, New York, NY 10065 USA

[5] Weill Cornell Med Coll, Dept Med, 1300 York Ave, New York, NY 10065 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 25卷 / 04期

关键词：

Sarcoma; Liposarcoma; Myxoid liposarcoma; Pleomorphic liposarcoma; CDK4; MDM2; FUS-CHOP; Trabectedin; SOFT-TISSUE SARCOMA; RANDOMIZED PHASE-II; DEDIFFERENTIATED LIPOSARCOMA; MYXOID LIPOSARCOMA; LIPOMATOUS TUMORS; CELL LIPOSARCOMA; MDM2; PROMOTES; EXTREMITY; SUBTYPE; CHEMOTHERAPY;

D O I：

10.1016/j.soc.2016.05.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There are 3 biologic groups of liposarcoma: well-differentiated and dedifferentiated liposarcoma, myxoid/round cell liposarcoma, and pleomorphic liposarcoma. In all 3 groups, complete surgical resection is central in treatment aimed at cure and is based on grade. Radiation can reduce risk of local recurrence in high-grade lesions or minimize surgical morbidity in the myxoid/round cell liposarcoma group. The groups differ in chemosensitivity, so adjuvant chemotherapy is selectively used in histologies with metastatic potential but not in the resistant subtype dedifferentiated liposarcoma. Improved understanding of the genetic aberrations that lead to liposarcoma initiation is allowing for the rapid development of targeted therapies for liposarcoma.

引用

页码：761 / +

页数：14

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