Hypertension linked to PDE3A activation

被引：13
作者：
Houslay, Miles [1 ,2 ]
机构：
[1] Kings Coll London, Inst Pharmaceut Sci, London, England
[2] Mironid Ltd, Biocity, Scotland
来源：
NATURE GENETICS | 2015年 / 47卷 / 06期
关键词：
PHOSPHODIESTERASE; ASSOCIATION; STROKE; PDE4D;
D O I：
10.1038/ng.3316
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A new study identifies PDE3A mutations as the cause of brachydactyly type E with hypertension. These mutations alter PDE3A activity by uncovering cryptic sites for phosphorylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.
引用
收藏
页码：562 / 563
页数：2
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