Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

被引：203

作者：

Lathia, Justin D. ^{[1
]}

Heddleston, John M. ^{[1
]}

Venere, Monica ^{[1
]}

Rich, Jeremy N. ^{[1
]}

机构：

[1] Cleveland Clin, Lerner Res Inst, Dept Stem Cell Biol & Regenerat Med, Cleveland, OH 44118 USA

来源：

CELL STEM CELL | 2011年 / 8卷 / 05期

关键词：

NICHE; HIF-2-ALPHA; EXPANSION; MAINTAINS; GLIOMAS;

D O I：

10.1016/j.stem.2011.04.013

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.

引用

页码：482 / 485

页数：4

共 21 条

[1] Genetic evidence for a tumor suppressor role of HIF-2α [J].

Acker, T ;

Diez-Juan, A ;

Aragones, J ;

Tjwa, M ;

Brusselmans, K ;

Moons, L ;

Fukumura, D ;

Moreno-Murciano, MP ;

Herbert, JM ;

Burger, A ;

Riedel, J ;

Elverl, G ;

Flamme, I ;

Maxwell, PH ;

Collen, D ;

Dewerchin, M ;

Jain, RK ;

Plate, KH ;

Carmeliet, P .

CANCER CELL, 2005, 8 (02) :131-141

[2] CANCER Tumour stem cells switch sides [J].

Bautch, Victoria L. .

NATURE, 2010, 468 (7325) :770-771

[3] CANCER GENETICS Initially complex, always heterogeneous [J].

Burgess, Darren J. .

NATURE REVIEWS CANCER, 2011, 11 (03) :153-153

[4] TRRAP and the Maintenance of Stemness in Gliomas [J].

Charles, Nikki A. ;

Holland, Eric C. .

CELL STEM CELL, 2010, 6 (01) :6-7

[5] NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts [J].

Fan, Xing ;

Khaki, Leila ;

Zhu, Thant S. ;

Soules, Mary E. ;

Talsma, Caroline E. ;

Gul, Naheed ;

Koh, Cheryl ;

Zhang, Jiangyang ;

Li, Yue-Ming ;

Maciaczyk, Jarek ;

Nikkhah, Guido ;

DiMeco, Francesco ;

Piccirillo, Sara ;

Vescovi, Angelo L. ;

Eberhart, Charles G. .

STEM CELLS, 2010, 28 (01) :5-16

[6] Making a tumour's bed: glioblastoma stem cells and the vascular niche [J].

Gilbertson, Richard J. ;

Rich, Jeremy N. .

NATURE REVIEWS CANCER, 2007, 7 (10) :733-736

[7] PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo [J].

Hambardzumyan, Dolores ;

Becher, Oren J. ;

Rosenblum, Marc K. ;

Pandolfi, Pier Paolo ;

Manova-Todorova, Katia ;

Holland, Eric C. .

GENES & DEVELOPMENT, 2008, 22 (04) :436-448

[8] The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype [J].

Heddleston, John M. ;

Li, Zhizhong ;

McLendon, Roger E. ;

Hjelmeland, Anita B. ;

Rich, Jeremy N. .

CELL CYCLE, 2009, 8 (20) :3274-3284

[9] Acidic stress promotes a glioma stem cell phenotype [J].

Hjelmeland, A. B. ;

Wu, Q. ;

Heddleston, J. M. ;

Choudhary, G. S. ;

MacSwords, J. ;

Lathia, J. D. ;

McLendon, R. ;

Lindner, D. ;

Sloan, A. ;

Rich, J. N. .

CELL DEATH AND DIFFERENTIATION, 2011, 18 (05) :829-840

[10]

Huse JT, 2011, GLIA

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