Contrasting characteristics of daily physical activity in older adults by cancer history

被引:29
作者
Wanigatunga, Amal A. [1 ,2 ]
Gresham, Gillian K. [1 ,3 ]
Kuo, Pei-Lun [1 ,2 ,4 ,5 ]
Martinez-Amezcua, Pablo [1 ,2 ]
Zipunnikov, Vadim [4 ]
Dy, Sydney M. [6 ]
Simonsick, Eleanor M. [5 ]
Ferrucci, Luigi [5 ]
Schrack, Jennifer A. [1 ,2 ,5 ]
机构
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, 2024 East Monument St,Room 2-724, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Ctr Aging & Hlth, Baltimore, MD USA
[3] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA
[5] NIA, Intramural Res Program, Baltimore, MD 21224 USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD USA
基金
美国国家卫生研究院;
关键词
accelerometer; activity transition; disease; fatigue; fragmentation; older adult; sedentary; MEASURED SEDENTARY TIME; SURVIVORS; HEALTH; ACCELEROMETER; ASSOCIATIONS; STATISTICS; MORTALITY; PATTERNS; BEHAVIOR; QUALITY;
D O I
10.1002/cncr.31745
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Using objectively collected physical activity (PA) data from the Baltimore Longitudinal Study of Aging, the authors tested whether patterns of daily activity and sedentary time differed by cancer survivorship in older adults. Methods In total, 659 participants (mean age +/- standard deviation, 71 +/- 10 years; 51% women) who had self-reported information on cancer history were instructed to wear an accelerometer for 7 consecutive days. Accelerometer data were summarized into: 1) PA volume and 2) activity fragmentation (interrupted activity), expressed as both continuous and as dichotomized (low and high) variables. Participants were categorized into 4 groups by cross-classification of dichotomous PA volume and fragmentation. Multiple regression models were used to estimate differences in PA patterns by cancer history. Results Cancer survivors averaged 0.12 fewer log-transformed activity counts per day (standard error, 0.05; P = .02) than individuals who reported no history of cancer after adjusting for demographics, behavioral factors, and comorbidities. Although fragmentation did not differ by cancer survivorship in the continuous model (P = .13), cancer survivorship was associated with 77% greater odds (odds ratio, 1.77; 95% confidence interval, 1.11-2.82) of having high (vs low) fragmentation and 94% greater odds (odds ratio, 1.94; 95% confidence interval, 1.13-3.33) of having combined low PA/high fragmentation (vs high PA/low fragmentation) relative to those with no cancer history. Conclusions The current findings suggest that cancer survivors engage in lower total daily PA and that they perform this activity in a more fragmented manner compared with adults without a history of cancer. These results may reflect the onset and progression of a low-activity phenotype that is more vulnerable to heightened levels of fatigue and functional decline with aging. Cancer 2018;124:4692-4699. (C) 2018 American Cancer Society.
引用
收藏
页码:4692 / 4699
页数:8
相关论文
共 34 条
[1]  
[Anonymous], 2012, J AGING RES
[2]  
[Anonymous], 2013, LANCET ONCOL, DOI DOI 10.1016/S1470-2045(13)70244-4
[3]   Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: From sarcopenic obesity to cachexia [J].
Biolo, Gianni ;
Cederholm, Tommy ;
Muscaritoli, Maurizio .
CLINICAL NUTRITION, 2014, 33 (05) :737-748
[4]   Lack of Exercise Is a Major Cause of Chronic Diseases [J].
Booth, Frank W. ;
Roberts, Christian K. ;
Laye, Matthew J. .
COMPREHENSIVE PHYSIOLOGY, 2012, 2 (02) :1143-1211
[5]   Residual risk of breast cancer recurrence 5 years after adjuvant therapy [J].
Brewster, Abenaa M. ;
Hortobagyi, Gabriel N. ;
Broglio, Kristine R. ;
Kau, Shu-Wan ;
Santa-Maria, Cesar A. ;
Arun, Banu ;
Buzdar, Arnan U. ;
Booser, Daniel J. ;
Valero, Vincente ;
Bondy, Melissa ;
Esteva, Francisco J. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (16) :1179-1183
[6]   Relationship between sedentary behaviour, physical activity, muscle quality and body composition in healthy older adults [J].
Chastin, Sebastien Francois Martin ;
Ferriolli, Eduardo ;
Stephens, Nathan A. ;
Fearon, Ken C. H. ;
Greig, Carolyn .
AGE AND AGEING, 2012, 41 (01) :111-114
[7]  
Davis MG, 2014, J AGING PHYS ACTIV, V22, P474, DOI [10.1123/JAPA.2013-0042, 10.1123/japa.2013-0042]
[8]   Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse [J].
Demaria, Marco ;
O'Leary, Monique N. ;
Chang, Jianhui ;
Shao, Lijian ;
Liu, Su ;
Alimirah, Fatouma ;
Koenig, Kristin ;
Le, Catherine ;
Mitin, Natalia ;
Deal, Allison M. ;
Alston, Shani ;
Academia, Emmeline C. ;
Kilmarx, Sumner ;
Valdovinos, Alexis ;
Wang, Boshi ;
de Bruin, Alain ;
Kennedy, Brian K. ;
Melov, Simon ;
Zhou, Daohong ;
Sharpless, Norman E. ;
Muss, Hyman ;
Campisi, Judith .
CANCER DISCOVERY, 2017, 7 (02) :165-176
[9]  
Deprez Sabine, 2018, J Natl Cancer Inst, V110, P223, DOI 10.1093/jnci/djx285
[10]   Patterns of Sedentary Behavior and Mortality in US Middle-Aged and Older Adults A National Cohort Study [J].
Diaz, Keith M. ;
Howard, Virginia J. ;
Hutto, Brent ;
Colabianchi, Natalie ;
Vena, John E. ;
Safford, Monika M. ;
Blair, Steven N. ;
Hooker, Steven P. .
ANNALS OF INTERNAL MEDICINE, 2017, 167 (07) :465-+